PRIM1 - DNA primase subunit 1 Gene

Homo sapiens

Also known as p49; PDIL

Gene ID: 5557 | Gene type: protein coding

About PRIM1

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,731,580-56,752,323 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 10.3), testis (RPKM 9.4) and 25 other tissues.

Summary

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA Polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]

PRIM1 Products(1)

mRNA	Protein	Name
NM_000946.3	NP_000937.1	DNA primase small subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA primase activity	IDA IDA: Inferred from direct assay	24043831	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	24043831	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables ribonucleotide binding	IDA IDA: Inferred from direct assay	24043831	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	24043831	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	26975377	GOA
involved in DNA replication, synthesis of primer	IDA IDA: Inferred from direct assay	8026492	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha DNA polymerase:primase complex	IDA IDA: Inferred from direct assay	8026492	GOA
part of alpha DNA polymerase:primase complex	IPI IPI: Inferred from physical interaction	26975377	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRIM1 Protein Structure

DNA_primase_S

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

DNA primase small subunit

DNA primase 1

PRIM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRIM1	P49642	PRIM2	Homo sapiens	P49643	Y2H Prey Pooling	32296183
Intra	PRIM1	P49642	PRIM2	Homo sapiens	P49643	Validated Y2H	32296183
Intra	PRIM1	P49642	PRIM2	Homo sapiens	P49643	Y2H Array	32296183
Intra	PRIM1	P49642	PRIM2	Homo sapiens	P49643	Anti Tag CoIP	33961781
Intra	PRIM1	P49642	PRIM2	Homo sapiens	P49643	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Primordial Dwarfism-Immunodeficiency-Lipodystrophy Syndrome

PDIL

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type	VEODS
Mrxsveod	Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type
X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type

Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11096	PRIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRIM1	VGNC	VGNC:49067
Mus musculus	PRIM1	MGD	MGI:97757
Rattus norvegicus	PRIM1	RGD	RGD:621380
Others	PRIM1	NCBI

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