SUPT20H - SPT20 homolog, SAGA complex component Gene

Homo sapiens

Also known as C13; FP757; P38IP; SPT20; FAM48A; C13orf19

Gene ID: 55578 | Gene type: protein coding

About SUPT20H

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:37,009,312-37,059,688 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and 2 paralogues. Broad expression in testis (RPKM 29.4), endometrium (RPKM 11.5) and 25 other tissues.

Summary

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Part of SAGA-type complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT20H Products(5)

mRNA	Protein	Name
NM_001014286.3	NP_001014308.2	transcription factor SPT20 homolog isoform a
NM_001278480.2	NP_001265409.1	transcription factor SPT20 homolog isoform c
NM_001278481.2	NP_001265410.1	transcription factor SPT20 homolog isoform b
NM_001278482.2	NP_001265411.1	transcription factor SPT20 homolog isoform b
NM_017569.4	NP_060039.1	transcription factor SPT20 homolog isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SAGA-type complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT20H Protein Structure

Spt20

0
200
400
600
779 a.a.

Protein Preferred Names

Protein Names

transcription factor SPT20 homolog

family with sequence similarity 48, member A

SUPT20H Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUPT20H	Q8NEM7	MAPK14	Homo sapiens	Q16539	Y2H Pooling	20936779
Intra	SUPT20H	Q8NEM7	MAPK14	Homo sapiens	Q16539	Anti Bait CoIP	16751104
Intra	SUPT20H	Q8NEM7	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	16751104
Intra	SUPT20H	Q8NEM7	MAPK14	Homo sapiens	Q16539	Y2H	16751104
Intra	SUPT20H	Q8NEM7	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Spinocerebellar Ataxia, X-Linked 3

Scax3	X-Linked Spinocerebellar Ataxia 3
X-Linked Ataxia-Deafness Syndrome	X-Linked Spinocerebellar Ataxia Type 3
Ataxia-Deafness Syndrome, X-Linked	Spinocerebellar Ataxia X-Linked Type 3
Ataxia-Deafness Syndrome X-Linked	X-Linked Ataxia-Hearing Loss Syndrome
Spinocerebellar Ataxia, X-Linked, 3

Spinocerebellar Ataxia, X-Linked 4

Scax4	X-Linked Spinocerebellar Ataxia 4
X-Linked Ataxia-Dementia Syndrome	X-Linked Spinocerebellar Ataxia Type 4
Ataxia-Dementia Syndrome, X-Linked	Spinocerebellar Ataxia X-Linked Type 4
Ataxia-Dementia Syndrome X-Linked	Spinocerebellar Ataxia, X-Linked, 4

Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8	ARMD8
Macular Degeneration, Age-Related, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14035	SUPT20H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SUPT20H	VGNC	VGNC:102339
Macaca mulatta	SUPT20H	VGNC	VGNC:78182
Bos taurus	SUPT20H	VGNC	VGNC:53835
Canis familiaris	SUPT20H	VGNC	VGNC:59097
Mus musculus	SUPT20H	MGD	MGI:1929651
Rattus norvegicus	SUPT20H	RGD	RGD:1307812

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