CHRNA9 - cholinergic receptor nicotinic alpha 9 subunit Gene

Homo sapiens

Also known as NACHRA9; HSA243342

Gene ID: 55584 | Gene type: protein coding

About CHRNA9

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,335,333-40,355,217 (from NCBI)

This gene has 3 transcripts (splice variants), 260 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

CHRNA9 Products(1)

mRNA	Protein	Name
NM_017581.4	NP_060051.2	neuronal acetylcholine receptor subunit alpha-9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	25282151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25282151	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of cytosolic calcium ion concentration	IGI IGI: Inferred from genetic interaction	18420419	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	25282151	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25282151	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRNA9 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit alpha-9

NACHR alpha 9

Related Diseases

Diseases

Alias

Tobacco Addiction

Nicotine Dependence	Tobacco Addiction, Susceptibility To
Nicotine Addiction	Tobacco Use Disorder
Smoking Habit	Nicotine Dependence, Protection Against
Nicotine Addiction, Protection From	Cigarette Habituation
Cigarette Habituation, Susceptibility To	Smoking Habit, Susceptibility To
Nicotine Dependence, Susceptibility To	Nicotine Addiction, Susceptibility To
Addiction, Tobacco, Susceptibility To	Compulsive Tobacco User Syndrome
Tobacco Dependence	Tobacco Dependence Syndrome
Cigarette Addiction	Cigarette Dependence
Smoking Addiction	Smokers Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02673	CHRNA9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHRNA9	VGNC	VGNC:27329
Canis familiaris	CHRNA9	VGNC	VGNC:39241
Felis catus	CHRNA9	VGNC	VGNC:78469
Macaca mulatta	CHRNA9	VGNC	VGNC:70947
Rattus norvegicus	CHRNA9	RGD	RGD:621534
Mus musculus	CHRNA9	MGD	MGI:1202403

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