ITLN1 - intelectin 1 Gene

Homo sapiens

Also known as HL1; LFR; HL-1; INTL; ITLN; hIntL; omentin

Gene ID: 55600 | Gene type: protein coding

About ITLN1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,876,540-160,885,180 (from NCBI)

This gene has 3 transcripts (splice variants), 259 orthologues and 1 paralogue. Biased expression in colon (RPKM 361.8), small intestine (RPKM 202.0) and 3 other tissues.

Summary

Enables calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Involved in positive regulation of glucose import; positive regulation of protein phosphorylation; and protein homotrimerization. Located in extracellular exosome. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

ITLN1 Products(1)

mRNA	Protein	Name
NM_017625.3	NP_060095.2	intelectin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	26148048	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26148048	GOA
enables oligosaccharide binding	IDA IDA: Inferred from direct assay	26148048	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26819645	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	16531507	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	16531507	GOA
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	26148048	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intelectin-1

ITLN-1

ITLN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ITLN1	Q8WWA0	DNAJC12	Homo sapiens	Q9UKB3	Anti Tag CoIP	28514442
Intra	ITLN1	Q8WWA0	ITLN2	Homo sapiens	Q8WWU7	Anti Tag CoIP	33961781
Intra	ITLN1	Q8WWA0	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	33961781
Intra	ITLN1	Q8WWA0	DNAJC12	Homo sapiens	Q9UKB3	Anti Tag CoIP	33961781
Intra	ITLN1	Q8WWA0	ITLN1	Homo sapiens	Q8WWA0	Comigration in SDS	26148048
Intra	ITLN1	Q8WWA0	ITLN2	Homo sapiens	Q8WWU7	Anti Tag CoIP	28514442
Intra	ITLN1	Q8WWA0	ENDOG	Homo sapiens	Q14249	Anti Tag CoIP	33961781
Intra	ITLN1	Q8WWA0	NACC1	Homo sapiens	Q96RE7	Anti Tag CoIP	28514442
Intra	ITLN1	Q8WWA0	NACC1	Homo sapiens	Q96RE7	Anti Tag CoIP	33961781
Intra	ITLN1	Q8WWA0	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	28514442
Intra	ITLN1	Q8WWA0	ENDOG	Homo sapiens	Q14249	Anti Tag CoIP	28514442
Intra	ITLN1	Q8WWA0	ITLN1	Homo sapiens	Q8WWA0	X-Ray Diffraction	26148048

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pleuropneumonia

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Nonobstructive Coronary Artery Disease

Non-Cad

Non-Obstructive Coronary Artery Disease

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Diabetes Mellitus

Diabetes

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06982	ITLN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ITLN1	RGD	RGD:1561048
Macaca mulatta	ITLN1	VGNC	VGNC:99984
Mus musculus	ITLN1	MGD	MGI:1333831
Others	ITLN1	NCBI

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