2. Gene
  3. NECAP2 - NECAP endocytosis associated 2 Gene

NECAP2 - NECAP endocytosis associated 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 55707 | Gene type: protein coding

About NECAP2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,440,724-16,460,078 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 34.8), spleen (RPKM 33.6) and 25 other tissues.

Summary

This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

NECAP2 Products(3)

mRNA Protein Name
NM_001145277.2 NP_001138749.1 adaptin ear-binding coat-associated protein 2 isoform 2
NM_001145278.2 NP_001138750.1 adaptin ear-binding coat-associated protein 2 isoform 3
NM_018090.5 NP_060560.1 adaptin ear-binding coat-associated protein 2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECAP2 Protein Structure

DUF1681

DUF1681: Protein of unknown function (DUF1681) (6 - 163)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

adaptin ear-binding coat-associated protein 2

adaptin-ear-binding coat-associated protein 2

Recombinant NECAP2 Proteins

Cat. No. Product Name Accession Purity
HY-P70922 NECAP2 Protein, Human (His) Q9NVZ3 (M1-F263) ≥95%

Related Diseases

Diseases Alias
Lissencephaly 8

LIS8
Congenital Anomalies Of Kidney And Urinary Tract 1

CAKUT1

Renal Hypodysplasia, Nonsyndromic, 1

Rhdns1

Congenital Anomalies Of The Kidney And Urinary Tract 1

Non-Syndromic Renal Hypodysplasia 1

Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1
Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24

Autosomal Recessive Spinocerebellar Ataxia 24

Spinocerebellar Ataxia, Autosomal Recessive, 24

Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Schuurs-Hoeijmakers Syndrome

SHMS

Pacs1-Related Syndrome

Mrd17

Intellectual Disability-Craniofacial Dysmorphism-Cryptorchidism Syndrome

Intellectual Developmental Disorder, Autosomal Dominant 17

Autosomal Dominant Intellectual Disability-17

Autosomal Dominant Mental Retardation 17

Pacs1 Syndrome

Mental Retardation, Autosomal Dominant 17
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09173 NECAP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NECAP2 VGNC VGNC:31981
Rattus norvegicus NECAP2 RGD RGD:735063
Canis familiaris NECAP2 VGNC VGNC:43717
Macaca mulatta NECAP2 VGNC VGNC:75255
Mus musculus NECAP2 MGD MGI:1913397
Others NECAP2 NCBI