TSR1 - TSR1 ribosome maturation factor Gene

Homo sapiens

Gene ID: 55720 | Gene type: protein coding

About TSR1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,322,396-2,336,457 (from NCBI)

This gene has 5 transcripts (splice variants), 224 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.8), esophagus (RPKM 10.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Predicted to be part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]

TSR1 Products(1)

mRNA	Protein	Name
NM_018128.5	NP_060598.3	pre-rRNA-processing protein TSR1 homolog

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSR1 Protein Structure

AARP2CN

RIBIOP_C

0
200
400
600
804 a.a.

Protein Preferred Names

Protein Names

pre-rRNA-processing protein TSR1 homolog

Related Diseases

Diseases

Alias

Epithelial Malignant Thymoma

Squamoid Thymoma	Thymoma, Epithelial
Well Differentiated Thymic Carcinoma	Thymoma, Type B3

Dendritic Cell Thymoma

Epithelioid Thymoma

Type B Thymoma

Geleophysic Dysplasia 3

GPHYSD3

Otomycosis

Singapore Ear

Geleophysic Dysplasia 2

GPHYSD2	Geleophysic Dwarfism
Dysplasia, Geleophysic, Type 2	Geleophysic Dysplasia

Geleophysic Dysplasia 1

GPHYSD1	Geleophysic Dwarfism
Geleophysic Dysplasia

Sick Building Syndrome

Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd

Peters-Plus Syndrome

Krause-Kivlin Syndrome	Peters Plus Syndrome
Peters Anomaly	Irido-Corneo-Trabecular Dysgenesis
PTRPLS	Peters Anomaly With Short-Limb Dwarfism
Peters Anomaly-Short Limb Dwarfism Syndrome	Peters Anomaly With Short Limb Dwarfism
Peters Congenital Glaucoma	Krause-Van Schooneveld-Kivlin Syndrome
Peters' Plus Syndrome	Peters'-Plus Syndrome
Anomaly Peters

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15184	TSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TSR1	VGNC	VGNC:36447
Rattus norvegicus	TSR1	RGD	RGD:2322150
Mus musculus	TSR1	MGD	MGI:2144566
Felis catus	TSR1	VGNC	VGNC:97669
Macaca mulatta	TSR1	VGNC	VGNC:79512
Macaca fascicularis	TSR1	NCBI	NCBI:102123844
Others	TSR1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.