ASF1B - anti-silencing function 1B histone chaperone Gene

Homo sapiens

Also known as CIA-II

Gene ID: 55723 | Gene type: protein coding

About ASF1B

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,119,512-14,136,589 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 265 orthologues and 1 paralogue. Biased expression in testis (RPKM 18.2), lymph node (RPKM 12.4) and 13 other tissues.

Summary

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]

ASF1B Products(1)

mRNA	Protein	Name
NM_018154.3	NP_060624.1	histone chaperone ASF1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone chaperone activity	IDA IDA: Inferred from direct assay	12842904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16980972	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	14718166	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASF1B Protein Structure

ASF1_hist_chap

0
100
202 a.a.

Protein Preferred Names

Protein Names

histone chaperone ASF1B

ASF1 anti-silencing function 1 homolog B

ASF1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASF1B	Q9NVP2	CHAF1B	Homo sapiens	Q13112	Anti Tag CoIP	28514442
Intra	ASF1B	Q9NVP2	CHAF1B	Homo sapiens	Q13112	Pull Down	16980972
Intra	ASF1B	Q9NVP2	CHAF1B	Homo sapiens	Q13112	Anti Bait CoIP	17353931
Intra	ASF1B	Q9NVP2	CHAF1B	Homo sapiens	Q13112	Anti Tag CoIP	33961781
Intra	ASF1B	Q9NVP2	H3-3A	Homo sapiens	P84243	GMS	26167883
Intra	ASF1B	Q9NVP2	HIRA	Homo sapiens	P54198	Anti Tag CoIP	33961781
Intra	ASF1B	Q9NVP2	HIRA	Homo sapiens	P54198	TAP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASF1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76157	ASF1B Protein, Human (sf9, His)	Q9NVP2 (M1-I202)	≥95%

Related Diseases

Diseases

Alias

Luminal Breast Carcinoma A

Breast Tumor Luminal	Luminal A Breast Carcinoma
Luminal Breast Cancer

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3	Cataract 34 Multiple Types
CTRCT34	Catc3
Cataract 34, Multiple Types, With Or Without Microcornea	Autosomal Recessive Congenital Cataract 3
Cataract 34 Multiple Types With Or Without Microcornea	Cataract, Multiple Types, Type 34

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01084	ASF1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ASF1B	MGD	MGI:1914179
Macaca mulatta	ASF1B	VGNC	VGNC:69872
Felis catus	ASF1B	VGNC	VGNC:59969
Bos taurus	ASF1B	VGNC	VGNC:50605
Rattus norvegicus	ASF1B	RGD	RGD:1304918
Others	ASF1B	NCBI

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