ARHGAP15 - Rho GTPase activating protein 15 Gene

Homo sapiens

Also known as BM046

Gene ID: 55843 | Gene type: protein coding

About ARHGAP15

Cytogenetic location: 2q22.2-q22.3 Genomic coordinates (GRCh38): 2:143,129,419-143,768,352 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 10.3), bone marrow (RPKM 9.8) and 18 other tissues.

Summary

RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

ARHGAP15 Products(1)

mRNA	Protein	Name
NM_018460.4	NP_060930.3	rho GTPase-activating protein 15

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	12650940	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of cell shape	IDA IDA: Inferred from direct assay	12650940	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP15 Protein Structure

RhoGAP

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 15

rho-type GTPase-activating protein 15

Related Diseases

Diseases

Alias

Diverticulitis

Mowat-Wilson Syndrome

MOWS	Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease
Hirschsprung Disease-Mental Retardation Syndrome	Mowat-Wilson Syndrome Due To Monosomy 2q22
Hirschsprung Disease Mental Retardation Syndrome	Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease
Hirschsprung Disease - Intellectual Disability Syndrome	Hirschsprung Disease Intellectual Disability Syndrome
Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease	Mws
Hirschsprung Disease-Intellectual Disability Syndrome	Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion
Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)	Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22
Mowat-Wilson Syndrome Due To 2q22 Microdeletion	Mowat-Wilson Syndrome Due To Del(2)Q(22)
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation	Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9	EIG9
Epilepsy, Juvenile Myoclonic 6	Idiopathic Generalized Epilepsy 9
Epilepsy, Juvenile Myoclonic, Susceptibility To, 6	Susceptibility To Idiopathic Generalized Epilepsy 9
Juvenile Myoclonic Epilepsy 6	EJM6
Susceptibility To Juvenile Myoclonic Epilepsy 6	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Diverticulitis Of Colon

Colonic Diverticular Disease	Diverticulitis, Colonic
Diverticular Disease Of Colon

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00916	ARHGAP15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARHGAP15	MGD	MGI:1923367
Felis catus	ARHGAP15	VGNC	VGNC:59876
Bos taurus	ARHGAP15	VGNC	VGNC:26076
Rattus norvegicus	ARHGAP15	RGD	RGD:1359304
Canis familiaris	ARHGAP15	VGNC	VGNC:38047
Macaca mulatta	ARHGAP15	VGNC	VGNC:69874

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