PKN2 - protein kinase N2 Gene

Homo sapiens

Also known as PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042

Gene ID: 5586 | Gene type: protein coding

About PKN2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:88,684,273-88,836,255 (from NCBI)

This gene has 6 transcripts (splice variants), 287 orthologues and 9 paralogues. Ubiquitous expression in ovary (RPKM 11.1), duodenum (RPKM 10.9) and 25 other tissues.

Summary

Enables RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Located in several cellular components, including cleavage furrow; cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

PKN2 Products(4)

mRNA	Protein	Name
NM_001320707.2	NP_001307636.1	serine/threonine-protein kinase N2 isoform 2
NM_001320708.2	NP_001307637.1	serine/threonine-protein kinase N2 isoform 3
NM_001320709.2	NP_001307638.1	serine/threonine-protein kinase N2 isoform 4
NM_006256.4	NP_006247.1	serine/threonine-protein kinase N2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase binding	IPI IPI: Inferred from physical interaction	15364941	GOA
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	20188095	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	15364941	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10026169	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20188095	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apical junction assembly	IMP IMP: Inferred from mutant phenotype	20974804	GOA
involved in epithelial cell migration	IDA IDA: Inferred from direct assay	21754995	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	17332740	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17332740	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	15364941	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17332740	GOA
involved in regulation of cell motility	IMP IMP: Inferred from mutant phenotype	21754995	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical junction complex	IDA IDA: Inferred from direct assay	20974804	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	17332740	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17332740	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11356191	GOA
located in midbody	IDA IDA: Inferred from direct assay	17332740	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11356191	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15364941	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23223530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKN2 Protein Structure

HR1

Pkinase

Pkinase_C

0
200
400
600
800
984 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase N2

PKN gamma

PKN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PKN2	Q16513	CETN2	Homo sapiens	P41208	Anti Tag CoIP	35271311
Intra	PKN2	Q16513	PDK1	Homo sapiens	Q15118	Protein Kinase Assay	17110931
Cross	PKN2	Q16513	O92972-PRO_0000278753	Hepatitis C virus	O92972-PRO_0000278753	ELISA	15364941
Cross	PKN2	Q16513	O92972-PRO_0000278753	Hepatitis C virus	O92972-PRO_0000278753	Anti Bait CoIP	15364941

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Mevalonic Aciduria

Mevalonate Kinase Deficiency	Mevalonicaciduria
Hyperimmunoglobulin D With Periodic Fever	MEVA
Complete Mevalonate Kinase Deficiency	Mva
Hyperimmunoglobulinemia D	Hyper Igd Syndrome
Periodic Fever, Dutch Type	Mkd
Aciduria, Mevalonic	Deficiency Of Mevalonate Kinase

Plague

Yersiniosis	Yersinia Infections
Infection By Yersinia Pestis	Pasteurella Pestis Infection
Pestilential Fever	Yersinia Pestis Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145899	PKN1/2-IN-1	Inhibitor	98.48%	Unkown
HY-RS10607	PKN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PKN2	VGNC	VGNC:32946
Macaca mulatta	PKN2	VGNC	VGNC:76015
Canis familiaris	PKN2	VGNC	VGNC:44612
Felis catus	PKN2	VGNC	VGNC:69064
Rattus norvegicus	PKN2	RGD	RGD:620146
Mus musculus	PKN2	MGD	MGI:109211
Others	PKN2	NCBI

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