WSB2 - WD repeat and SOCS box containing 2 Gene

Homo sapiens

Also known as SBA2

Gene ID: 55884 | Gene type: protein coding

About WSB2

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 28.5) and 25 other tissues.

Summary

This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

WSB2 Products(3)

mRNA	Protein	Name
NM_001278557.1	NP_001265486.1	WD repeat and SOCS box-containing protein 2 isoform 1
NM_001278558.2	NP_001265487.1	WD repeat and SOCS box-containing protein 2 isoform 3
NM_018639.5	NP_061109.1	WD repeat and SOCS box-containing protein 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WSB2 Protein Structure

WD40

SOCS_box

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

WD repeat and SOCS box-containing protein 2

CS box-containing WD protein

WSB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WSB2	Q9NYS7	PFDN2	Homo sapiens	Q9UHV9	Lumier	25036637
Intra	WSB2	Q9NYS7	PFDN2	Homo sapiens	Q9UHV9	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15850	WSB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WSB2	VGNC	VGNC:36972
Canis familiaris	WSB2	VGNC	VGNC:48436
Mus musculus	WSB2	MGD	MGI:2144041
Rattus norvegicus	WSB2	RGD	RGD:1359599
Felis catus	WSB2	VGNC	VGNC:67092

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