ACSS2 - acyl-CoA synthetase short chain family member 2 Gene

Homo sapiens

Also known as ACS; ACSA; ACAS2; ACECS; AceCS1; dJ1161H23.1

Gene ID: 55902 | Gene type: protein coding

About ACSS2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,874,989-34,927,959 (from NCBI)

This gene has 24 transcripts (splice variants), 219 orthologues and 13 paralogues. Broad expression in fat (RPKM 49.2), duodenum (RPKM 47.1) and 24 other tissues.

Summary

This gene encodes a cytosolic Enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of Cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

ACSS2 Products(3)

mRNA	Protein	Name
NM_001076552.3	NP_001070020.2	acetyl-coenzyme A synthetase, cytoplasmic isoform 2
NM_001242393.2	NP_001229322.1	acetyl-coenzyme A synthetase, cytoplasmic isoform 3
NM_018677.4	NP_061147.1	acetyl-coenzyme A synthetase, cytoplasmic isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetate-CoA ligase activity	IDA IDA: Inferred from direct assay	10843999	GOA
enables acetate-CoA ligase activity	IMP IMP: Inferred from mutant phenotype	28552616	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28552616	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	10843999	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	28003429	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28552616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSS2 Protein Structure

AMP-binding

AMP-binding_C

0
200
400
600
701 a.a.

Protein Preferred Names

Protein Names

acetyl-coenzyme A synthetase, cytoplasmic

acetate thiokinase

ACSS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82238	ACSS2 Antibody (YA1983)	WB	Human

Related Diseases

Diseases

Alias

Orofacial Cleft 1

OFC1	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1
Orofacial Cleft, Nonsyndromic	Ofc
Cleft Lip/Palate, Nonsyndromic	Orofacial Cleft-1
Nonsyndromic Cleft Lip With Or Without Cleft Palate 1	Nonsyndromic Cleft Lip Palate
Otofaciocervical Syndrome 1

Cardiomyopathy, Infantile Histiocytoid

Histiocytoid Cardiomyopathy	Foamy Myocardial Transformation Of Infancy
Infantile Histiocytoid Cardiomyopathy	Infantile Xanthomatous Cardiomyopathy
Oncocytic Cardiomyopathy	Cardiomyopathy, Infantile Xanthomatous
Cardiomyopathy, Focal Lipid	Cardiomyopathy, Oncocytic
Focal Lipid Cardiomyopathy	Infantile Cardiomyopathy With Histiocytoid Change
CMIH	Cardiomyopathy Focal Lipid
Cardiomyopathy Infantile Xanthomatous	Cardiomyopathy Oncocytic

Canavan Disease

Aspartoacylase Deficiency	Aminoacylase 2 Deficiency
Spongy Degeneration Of Central Nervous System	Aspa Deficiency
Acy2 Deficiency	Canavan-Van Bogaert-Bertrand Disease
Mild Canavan Disease	Asp Deficiency
Spongy Degeneration Of The Central Nervous System	Severe Canavan Disease
Von Bogaert-Bertrand Disease	Canavan'S Disease
Spongy Degeneration Of The Brain	Juvenile Canavan Disease
Infantile Canavan Disease	Neonatal Canavan Disease
CAND	Disease, Canavan
Canavan Disease, Juvenile	Canavan Disease, Infantile
Canavan Disease, Neonatal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104032	Ac-CoA Synthase Inhibitor1	Inhibitor	99.33%	Unkown
HY-145953	VY-3-135	Inhibitor	99.62%	Unkown
HY-148104	ACSS2-IN-2	Inhibitor	99.49%	Unkown
HY-161116	AD-5584	Inhibitor	95.31%	Unkown
HY-161117	AD-8007	Inhibitor	/	Unkown
HY-145392	ACSS2-IN-1	Inhibitor	/	Unkown
HY-RS00211	ACSS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACSS2	RGD	RGD:1305489
Felis catus	ACSS2	VGNC	VGNC:79978
Bos taurus	ACSS2	VGNC	VGNC:25571
Mus musculus	ACSS2	MGD	MGI:1890410
Macaca mulatta	ACSS2	VGNC	VGNC:69410
Canis familiaris	ACSS2	VGNC	VGNC:37537
Others	ACSS2	NCBI

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