BIN3 - bridging integrator 3 Gene

Homo sapiens

Gene ID: 55909 | Gene type: protein coding

About BIN3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,620,418-22,669,121 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 13.5), adrenal (RPKM 7.2) and 25 other tissues.

Summary

The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of Other processes. [provided by RefSeq, Jul 2008]

BIN3 Products(2)

mRNA	Protein	Name
NM_001363046.2	NP_001349975.1	bridging integrator 3 isoform 2
NM_018688.6	NP_061158.1	bridging integrator 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18654987	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization	IMP IMP: Inferred from mutant phenotype	11274158	GOA
involved in unidimensional cell growth	IMP IMP: Inferred from mutant phenotype	11274158	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIN3 Protein Structure

BAR

0
100
200
253 a.a.

Protein Preferred Names

Protein Names

bridging integrator 3

BIN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BIN3	Q9NQY0	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	BIN3	Q9NQY0	DNMBP	Homo sapiens	Q6XZF7	Anti Tag CoIP	35271311
Intra	BIN3	Q9NQY0	DNMBP	Homo sapiens	Q6XZF7	Anti Tag CoIP	33961781
Intra	BIN3	Q9NQY0	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	BIN3	Q9NQY0	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 10

RP10	Retinitis Pigmentosa-10
Retinitis Pigmentosa, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147830	PDE4B-IN-3	Inhibitor	99.40%	Unkown
HY-15133	PTP1B-IN-3	Inhibitor	99.35%	Unkown
HY-15133A	PTP1B-IN-3 diammonium	Inhibitor	95.38%	Unkown
HY-139600	KDM2B-IN-3	Inhibitor	/	Unkown
HY-146429	NaPi2b-IN-3	Inhibitor	/	Unkown
HY-146670	KDM5B-IN-3	Inhibitor	/	Unkown
HY-147605	Factor B-IN-3	Inhibitor	/	Unkown
HY-149379	DNA gyrase B-IN-3	Inhibitor	/	Unkown
HY-151885	Dual AChE-MAO B-IN-3	Inhibitor	/	Unkown
HY-RS01506	BIN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BIN3	MGD	MGI:1929883
Macaca mulatta	BIN3	VGNC	VGNC:70252
Canis familiaris	BIN3	VGNC	VGNC:54923
Felis catus	BIN3	VGNC	VGNC:60118
Rattus norvegicus	BIN3	RGD	RGD:1308253
Bos taurus	BIN3	VGNC	VGNC:52607

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