NXF2 - nuclear RNA export factor 2 Gene

Homo sapiens

Also known as CT39; TAPL-2; TCP11X2

Gene ID: 56001 | Gene type: protein coding

About NXF2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:102,247,167-102,326,722 (from NCBI)

This gene has 2 transcripts (splice variants), 263 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 10.2).

Summary

This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]

NXF2 Products(1)

mRNA	Protein	Name
NM_022053.4	NP_071336.1	nuclear RNA export factor 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	11566096	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nuclear RNA export factor complex	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXF2 Protein Structure

Tap-RNA_bind

NTF2

TAP_C

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

nuclear RNA export factor 2

TAP-like protein 2

NXF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NXF2B	Q9GZY0	NXT2	Homo sapiens	Q9NPJ8-3	Validated Y2H	32296183
Intra	NXF2B	Q9GZY0	HEXB	Homo sapiens	P07686	Y2H Pooling	32814053
Intra	NXF2B	Q9GZY0	HEXB	Homo sapiens	P07686	Validated Y2H	32814053
Intra	NXF2B	Q9GZY0	HEXB	Homo sapiens	P07686	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Progesterone-Receptor Negative Breast Cancer

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09711	NXF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.