PRM2 - protamine 2 Gene

Homo sapiens

Also known as CT94.2

Gene ID: 5620 | Gene type: protein coding

About PRM2

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,275,639-11,276,480 (from NCBI)

This gene has 2 transcripts (splice variants) and 44 orthologues. Restricted expression toward testis (RPKM 2357.8).

Summary

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 Peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]

PRM2 Products(5)

mRNA	Protein	Name
NM_001286356.2	NP_001273285.1	protamine-2 isoform 2
NM_001286357.2	NP_001273286.1	protamine-2 isoform 3
NM_001286358.2	NP_001273287.1	protamine-2 isoform 4
NM_001286359.2	NP_001273288.1	protamine-2 isoform 5
NM_002762.4	NP_002753.2	protamine-2 isoform 1

PRM2 Protein Structure

Protamine_P2

0
102 a.a.

Protein Preferred Names

Protein Names

protamine-2

cancer/testis antigen family 94, member 2

PRM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRM2	P04554	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	PRM2	P04554	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	PRM2	P04554	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	PRM2	P04554	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	PRM2	P04554	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	PRM2	P04554	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	PRM2	P04554	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	PRM2	P04554	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	PRM2	P04554	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Oligospermia

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11165	PRM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRM2	MGD	MGI:97766
Bos taurus	PRM2	VGNC	VGNC:58610
Rattus norvegicus	PRM2	RGD	RGD:3409

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