2. Gene
  3. Fgf21 - fibroblast growth factor 21 Gene

Fgf21 - fibroblast growth factor 21 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fgf8c

Gene ID: 56636 | Gene type: protein coding

About Fgf21

Summary

Predicted to enable Fibroblast Growth Factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; cerebellum; integumental system; limb; and skeleton. Orthologous to human FGF21 (Fibroblast Growth Factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Fgf21 Products(1)

mRNA Protein Name
NM_020013.4 NP_064397.1 fibroblast growth factor 21 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18187602 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18187602 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22302939 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
30605666 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 21

fibroblast growth factor 8c

Recombinant Fgf21 Proteins

Cat. No. Product Name Accession Purity
HY-P7173 FGF-21 Protein, Mouse Q9JJN1 (A29-S210) ≥95%
HY-P72651 FGF-21 Protein, Mouse (HEK293, His) Q9JJN1 (A29-S210) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99930 Efruxifermin Activator / Phase 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf21 NCBI NCBI:26291
Macaca fascicularis Fgf21 NCBI NCBI:102126624