FGF21 - fibroblast growth factor 21 Gene

Homo sapiens

Gene ID: 26291 | Gene type: protein coding

About FGF21

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,755,524-48,758,330 (from NCBI)

This gene has 2 transcripts (splice variants), 103 orthologues and 21 paralogues. Restricted expression toward liver (RPKM 3.0).

Summary

Theis gene encodes a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]

FGF21 Products(1)

mRNA	Protein	Name
NM_019113.4	NP_061986.1	fibroblast growth factor 21 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18829467	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	17623664	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17623664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF21 Protein Structure

FGF

0
100
209 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor 21

FGF21 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FGF21	Q9NSA1	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	FGF21	Q9NSA1	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	FGF21	Q9NSA1	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	FGF21	Q9NSA1	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	FGF21	Q9NSA1	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	FGF21	Q9NSA1	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	FGF21	Q9NSA1	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	FGF21	Q9NSA1	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	FGF21	Q9NSA1	KLB	Homo sapiens	Q86Z14	SPR	19059246

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FGF21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7012	FGF-21 Protein, Human	Q9NSA1 (H29-S209,with an N-terminal Gly)	≥95%
HY-P7345	FGF-21 Protein, Human (CHO, His)	Q9NSA1 (H29-S209)	≥95%
HY-P70473	FGF-21 Protein, Human (His)	AAH18404.1 (H29-S209)	≥95%
HY-P78442	FGF-21 Protein, Human (HEK293, mFc-Avi)	Q9NSA1 (H29-S209)	≥95%
HY-P70473AF	Animal-Free FGF-21 Protein, Human (His)	Q9NSA1 (H29-S209)	≥95%
HY-P700719	FGF-21 Protein, Human (Biotinylated, HEK293, mFc-Avi)	Q9NSA1 (H29-S209)	≥95%
HY-P701092	FGF-21 Protein, Human (181a.a)	Q9NSA1 (H29-S209)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Clear Cell Carcinoma

Clear Cell Carcinoma Of The Liver Cells	Hepatocellular Carcinoma, Clear Cell Type
Clear Cell Hepatocellular Carcinoma

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Epilepsy, Idiopathic Generalized 4

EIG4	Epilepsy, Idiopathic Generalized, Susceptibility To 4
Idiopathic Generalized Epilepsy 4	Epilepsy, Idiopathic Generalized, Susceptibility To, 4
Epilepsy, Idiopathic Generalized Locus On Chromosome 10	Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Cardiac Arrest

Cardiopulmonary Arrest	Circulatory Arrest
Heart Arrest

Friedreich Ataxia

Friedreich Ataxia 1	FRDA
Friedreich Ataxia With Retained Reflexes	Frda1
Fa	Friedreich'S Ataxia
Hereditary Spinal Ataxia	Fa1
Friedreich'S Tabes	Hereditary Spinal Sclerosis
Spinocerebellar Ataxia, Friedreich	Friedreich Spinocerebellar Ataxia
Friedrich'S Ataxia

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Non-Alcoholic Steatohepatitis

Nonalcoholic Steatohepatitis	Nash
Nash - [Non-Alcoholic Steatohepatitis]	Non-Alcoholic Steatohepatosis

Lipid Storage Disease

Lipoidosis	Inborn Lipid Storage Disorder
Lipoid Storage Diseas	Lipid Storage Diseases
Lipidoses

Diabetes Mellitus

Diabetes

Alcoholic Cardiomyopathy

Cardiomyopathy, Alcoholic	Alcohol-Induced Heart Muscle Disease
Dilated Cardiomyopathy Secondary To Alcohol

Overnutrition

Acquired Metabolic Disease

Lysosomal Storage Disease

Lysosomal Storage Diseases	Disorder Of Lysosomal Enzyme
Inborn Lysosomal Enzyme Disorder	Lysosomal Storage Metabolism Disorder
Lysosomal Storage Disorder

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Melas Syndrome	MELAS
Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes	Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke
Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes	Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome
Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99930	Efruxifermin	Activator	/	Phase 3

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FGF21	VGNC	VGNC:72647
Felis catus	FGF21	VGNC	VGNC:62252
Canis familiaris	FGF21	VGNC	VGNC:40848
Mus musculus	FGF21	MGD	MGI:1861377
Rattus norvegicus	FGF21	RGD	RGD:620175
Bos taurus	FGF21	VGNC	VGNC:28977
Macaca fascicularis	FGF21	NCBI	NCBI:102126624
Others	FGF21	NCBI

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