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  2. BCCIP - BRCA2 and CDKN1A interacting protein Gene

BCCIP - BRCA2 and CDKN1A interacting protein Gene

Homo sapiens

Also known as TOK1; TOK-1

Gene ID: 56647 | Gene type: protein coding

About BCCIP

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,823,546-125,853,695 (from NCBI)

This gene has 5 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in testis (RPKM 16.0), ovary (RPKM 12.3) and 25 other tissues.

Summary

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of Calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

BCCIP Products(3)

mRNA Protein Name
NM_016567.4 NP_057651.1 BRCA2 and CDKN1A-interacting protein isoform BCCIPalpha
NM_078468.3 NP_510868.1 BRCA2 and CDKN1A-interacting protein isoform BCCIPbeta
NM_078469.3 NP_510869.1 BRCA2 and CDKN1A-interacting protein isoform C

BCCIP Protein Structure

BCIP

BCIP: p21-C-terminal region-binding protein (55 - 257)

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  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

BRCA2 and CDKN1A-interacting protein

BCCIPalpha

Recombinant BCCIP Proteins

Cat. No. Product Name Accession Purity
HY-P76746 BCCIP Protein, Human (sf9) Q9P287-1 (N-G&P, M1-V314) ≥95%
HY-P76747 BCCIP Protein, Human (sf9, His-GST) Q9P287-1 (M1-V314) ≥95%

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCCIP VGNC VGNC:100299
Canis familiaris BCCIP VGNC VGNC:38403
Bos taurus BCCIP VGNC VGNC:26441
Rattus norvegicus BCCIP RGD RGD:1307362
Mus musculus BCCIP MGD MGI:1913415
Others BCCIP NCBI