2. Gene
  3. BCCIP - BRCA2 and CDKN1A interacting protein Gene

BCCIP - BRCA2 and CDKN1A interacting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TOK1; TOK-1

Gene ID: 56647 | Gene type: protein coding

About BCCIP

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,823,546-125,853,695 (from NCBI)

This gene has 5 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in testis (RPKM 16.0), ovary (RPKM 12.3) and 25 other tissues.

Summary

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of Calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

BCCIP Products(3)

mRNA Protein Name
NM_016567.4 NP_057651.1 BRCA2 and CDKN1A-interacting protein isoform BCCIPalpha
NM_078468.3 NP_510868.1 BRCA2 and CDKN1A-interacting protein isoform BCCIPbeta
NM_078469.3 NP_510869.1 BRCA2 and CDKN1A-interacting protein isoform C
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinase regulator activity IDA
IDA: Inferred from direct assay
10878006 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables tubulin binding IDA
IDA: Inferred from direct assay
28394342 GOA
Biological Process GO Annotation Evidence Reference Source
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
28394342 GOA
involved in microtubule anchoring IMP
IMP: Inferred from mutant phenotype
28394342 GOA
involved in microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
28394342 GOA
involved in mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
28394342 GOA
involved in mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
28394342 GOA
involved in neuroendocrine cell differentiation IDA
IDA: Inferred from direct assay
18440304 GOA
acts upstream of or within regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10878006 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
28394342 GOA
located in centrosome IDA
IDA: Inferred from direct assay
28394342 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
28394342 GOA
part of nuclear cyclin-dependent protein kinase holoenzyme complex IDA
IDA: Inferred from direct assay
10878006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCCIP Protein Structure

BCIP

BCIP: p21-C-terminal region-binding protein (55 - 257)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

BRCA2 and CDKN1A-interacting protein

BCCIPalpha

Recombinant BCCIP Proteins

Cat. No. Product Name Accession Purity
HY-P76746 BCCIP Protein, Human (sf9) Q9P287-1 (N-G&P, M1-V314) ≥95%
HY-P76747 BCCIP Protein, Human (sf9, His-GST) Q9P287-1 (M1-V314) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01404 BCCIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCCIP VGNC VGNC:100299
Canis familiaris BCCIP VGNC VGNC:38403
Bos taurus BCCIP VGNC VGNC:26441
Rattus norvegicus BCCIP RGD RGD:1307362
Mus musculus BCCIP MGD MGI:1913415
Others BCCIP NCBI