RPL23 - ribosomal protein L23 Gene

Homo sapiens

Also known as L23; rpL17

Gene ID: 9349 | Gene type: protein coding

About RPL23

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,847,860-38,853,721 (from NCBI)

This gene has 11 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in ovary (RPKM 1299.4), bone marrow (RPKM 656.3) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL23 Products(1)

mRNA	Protein	Name
NM_000978.4	NP_000969.1	60S ribosomal protein L23

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15314173	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	19160485	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: Inferred from direct assay	15314173	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15314173	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of positive effect G1 to G0 transition	IMP IMP: Inferred from mutant phenotype	19160485	GOA
involved in cellular response to actinomycin D	IMP IMP: Inferred from mutant phenotype	15314173	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19160485	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15314173	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15314173	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19160485	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15314173	GOA
involved in positive regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15314173	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	15314173	GOA
involved in protein-DNA complex disassembly	IDA IDA: Inferred from direct assay	19160485	GOA
acts upstream of positive effect regulation of G1 to G0 transition	IMP IMP: Inferred from mutant phenotype	15314173	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15314173	GOA
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15314173	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	15314173	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19160485	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15314173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL23 Protein Structure

Ribosomal_L14

0
100
140 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L23

60S ribosomal protein L17

RPL23 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPL23	P62829	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RPL23	P62829	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RPL23	P62829	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RPL23	P62829	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17110929
Intra	RPL23	P62829	MDM2	Homo sapiens	Q00987	Y2H	17310983
Intra	RPL23	P62829	BCCIP	Homo sapiens	Q9P287	Validated Y2H	32296183
Intra	RPL23	P62829	BCCIP	Homo sapiens	Q9P287	Validated Y2H	25416956
Intra	RPL23	P62829	BCCIP	Homo sapiens	Q9P287	Y2H Array	25416956
Intra	RPL23	P62829	BCCIP	Homo sapiens	Q9P287	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS	Sedaghatian Chondrodysplasia
Spondylometaphyseal Dysplasia Sedaghatian Type	Congenital Lethal Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia, Congenital Lethal	Lethal Metaphyseal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12175	RPL23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12176	RPL23A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPL23	MGD	MGI:1929455
Rattus norvegicus	RPL23	RGD	RGD:62067
Macaca mulatta	RPL23	VGNC	VGNC:104646
Felis catus	RPL23	VGNC	VGNC:99437
Bos taurus	RPL23	VGNC	VGNC:55867

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