2. Gene
  3. KCNK13 - potassium two pore domain channel subfamily K member 13 Gene

KCNK13 - potassium two pore domain channel subfamily K member 13 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as THIK1; THIK-1; K2p13.1

Gene ID: 56659 | Gene type: protein coding

About KCNK13

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,061,994-90,185,853 (from NCBI)

This gene has 1 transcript (splice variant), 249 orthologues and 14 paralogues. Biased expression in testis (RPKM 6.7), kidney (RPKM 2.6) and 6 other tissues.

Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a Potassium Channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]

KCNK13 Products(1)

mRNA Protein Name
NM_022054.4 NP_071337.2 potassium channel subfamily K member 13

KCNK13 Protein Structure

Ion_trans_2

Ion_trans_2: Ion channel (93 - 150)

Ion_trans_2

Ion_trans_2: Ion channel (198 - 283)

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  • 408 a.a.
Protein Preferred Names Protein Names

potassium channel subfamily K member 13

K2P13.1 potassium channel

Related Diseases

Diseases Alias
Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome

BIBARS

Mental Retardation With Hypotonia And Facial Dysmorphism

Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

Kcnk9 Imprinting Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-158155 CVN293 Inhibitor 99.91% Unkown
HY-161158 KCNK13-IN-1 Antagonist 98.3% Unkown
HY-RS07155 KCNK13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KCNK13 VGNC VGNC:104479
Macaca mulatta KCNK13 VGNC VGNC:82167
Bos taurus KCNK13 VGNC VGNC:106791
Rattus norvegicus KCNK13 RGD RGD:68941
Mus musculus KCNK13 MGD MGI:2384976
Canis familiaris KCNK13 VGNC VGNC:53499