2. Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Potassium Channel NOD-like Receptor (NLR)
  4. CVN293

CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.

For research use only. We do not sell to patients.

CVN293 Chemical Structure

CVN293 Chemical Structure

CAS No. : 2815296-08-1

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Based on 1 publication(s) in Google Scholar

CVN293 Related Antibodies

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NLRP3 NLRP1 NOD1 NOD2

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Description

CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia[1].

IC50 & Target[1]

hKCNK13

41 nM (IC50)

mKCNK13

28 nM (IC50)

hKCNK6

>30000 nM (IC50)

hKCNK2

>30000 nM (IC50)

In Vitro

CVN293 (0.05, 0.5, 5 μM) demonstrates a concentration-dependent inhibition of the NLRP3-inflammasome mediated production of IL-1β from LPS-primed murine microglia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CVN293 Related Antibodies
In Vivo

Pharmacokinetic Parameters of CVN293 in male Sprague-Dawley rat, dog and cynomolgus monkey[1].

IV (0.5 mg/kg; rat) PO (3 mg/kg; rat) IV (1 mg/kg; dog) PO (10 mg/kg; dog) IV (1 mg/kg; cynomolgus monkey) PO (3 mg/kg; cynomolgus monkey)
Tmax (h) 1.0 1.25 1.0
Cmax (ng/mL) 468 241 165
AUC0-∞ (ng•h/mL) 222 1236 438 630 782 546
t1/2 (h) 1.0 2.0 0.5 2.6 1.1 1.9
CLp (mL/min/kg) 35 38 22
Vss (L/kg) 1.85 1.42 1.45
F (%) 87 41 24

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

311.27

Formula

C14H10FN7O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=NN=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (16.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2126 mL 16.0632 mL 32.1264 mL
5 mM 0.6425 mL 3.2126 mL 6.4253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2126 mL 16.0632 mL 32.1265 mL 80.3161 mL
5 mM 0.6425 mL 3.2126 mL 6.4253 mL 16.0632 mL
10 mM 0.3213 mL 1.6063 mL 3.2126 mL 8.0316 mL
15 mM 0.2142 mL 1.0709 mL 2.1418 mL 5.3544 mL
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CVN293 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CVN2932815296-08-1CVN 293CVN-293Potassium ChannelNOD-like Receptor (NLR)KcsAbrain permeablepotassium ion channelKCNK13proinflammatory cytokineIL-1βmicrogliaInhibitorinhibitorinhibit

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