2. Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Potassium Channel NOD-like Receptor (NLR)
  4. CVN293

CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.

For research use only. We do not sell to patients.

CVN293 Chemical Structure

CVN293 Chemical Structure

CAS No. : 2815296-08-1

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Based on 1 publication(s) in Google Scholar

CVN293 Related Antibodies

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NLRP3 NLRP1 NOD1 NOD2

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Description

CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia[1].

IC50 & Target[1]

hKCNK13

41 nM (IC50)

mKCNK13

28 nM (IC50)

hKCNK6

>30000 nM (IC50)

hKCNK2

>30000 nM (IC50)

In Vitro

CVN293 (0.05, 0.5, 5 μM) demonstrates a concentration-dependent inhibition of the NLRP3-inflammasome mediated production of IL-1β from LPS-primed murine microglia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CVN293 Related Antibodies
In Vivo

Pharmacokinetic Parameters of CVN293 in male Sprague-Dawley rat, dog and cynomolgus monkey[1].

IV (0.5 mg/kg; rat) PO (3 mg/kg; rat) IV (1 mg/kg; dog) PO (10 mg/kg; dog) IV (1 mg/kg; cynomolgus monkey) PO (3 mg/kg; cynomolgus monkey)
Tmax (h) 1.0 1.25 1.0
Cmax (ng/mL) 468 241 165
AUC0-∞ (ng•h/mL) 222 1236 438 630 782 546
t1/2 (h) 1.0 2.0 0.5 2.6 1.1 1.9
CLp (mL/min/kg) 35 38 22
Vss (L/kg) 1.85 1.42 1.45
F (%) 87 41 24

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

311.27

Formula

C14H10FN7O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=NN=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (16.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2126 mL 16.0632 mL 32.1264 mL
5 mM 0.6425 mL 3.2126 mL 6.4253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

SDS (251 KB)

COA (260 KB) HNMR (253 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2126 mL 16.0632 mL 32.1265 mL 80.3161 mL
5 mM 0.6425 mL 3.2126 mL 6.4253 mL 16.0632 mL
10 mM 0.3213 mL 1.6063 mL 3.2126 mL 8.0316 mL
15 mM 0.2142 mL 1.0709 mL 2.1418 mL 5.3544 mL
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CVN293 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CVN2932815296-08-1CVN 293CVN-293Potassium ChannelNOD-like Receptor (NLR)KcsAbrain permeablepotassium ion channelKCNK13proinflammatory cytokineIL-1βmicrogliaInhibitorinhibitorinhibit

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