SUCNR1 - succinate receptor 1 Gene

Homo sapiens

Also known as GPR91

Gene ID: 56670 | Gene type: protein coding

About SUCNR1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:151,873,643-151,884,619 (from NCBI)

This gene has 1 transcript (splice variant), 211 orthologues and 15 paralogues. Biased expression in kidney (RPKM 20.6), thyroid (RPKM 7.3) and 7 other tissues.

Summary

This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]

SUCNR1 Products(1)

mRNA	Protein	Name
NM_033050.6	NP_149039.2	succinate receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	18820681	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18820681	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15141213	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUCNR1 Protein Structure

7tm_1

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

succinate receptor 1

G-protein coupled receptor 91

P2Y purinoceptor 1

SUCNR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUCNR1	Q9BXA5	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	SUCNR1	Q9BXA5	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	SUCNR1	Q9BXA5	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	SUCNR1	Q9BXA5	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	SUCNR1	Q9BXA5	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	SUCNR1	Q9BXA5	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	SUCNR1	Q9BXA5	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	SUCNR1	Q9BXA5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SUCNR1	Q9BXA5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Renovascular Hypertension

Hypertension, Renovascular

Hypertension Renovascular

Mooren'S Ulcer

Mooren Ulcer

Moorens Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130246	NF-56-EJ40		99.92%	Unkown
HY-125791	cis-Epoxysuccinic acid	Agonist	99.00%	Unkown
HY-154946	SUCNR1-IN-1	Inhibitor	99.33%	Unkown
HY-RS14004	Sucnr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-156955	SUCNR1-IN-2		99.74%	Unkown
HY-130246A	NF-56-EJ40 hydrochloride		/	Unkown
HY-RS14003	SUCNR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14005	Sucnr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SUCNR1	MGD	MGI:1934135
Canis familiaris	SUCNR1	VGNC	VGNC:46968
Macaca mulatta	SUCNR1	VGNC	VGNC:110337
Rattus norvegicus	SUCNR1	RGD	RGD:1303193
Felis catus	SUCNR1	VGNC	VGNC:67448
Bos taurus	SUCNR1	VGNC	VGNC:35458

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