BMAL2 - basic helix-loop-helix ARNT like 2 Gene

Homo sapiens

Also known as CLIF; MOP9; PASD9; ARNTL2; bHLHe6

Gene ID: 56938 | Gene type: protein coding

About BMAL2

Cytogenetic location: 12p11.23 Genomic coordinates (GRCh38): 12:27,332,836-27,425,286 (from NCBI)

This gene has 9 transcripts (splice variants), 245 orthologues and 6 paralogues. Broad expression in esophagus (RPKM 6.4), appendix (RPKM 3.2) and 17 other tissues.

Summary

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

BMAL2 Products(11)

mRNA	Protein	Name
NM_001248002.3	NP_001234931.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2
NM_001248003.3	NP_001234932.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 3
NM_001248004.3	NP_001234933.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 4
NM_001248005.3	NP_001234934.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 5
NM_001394524.1	NP_001381453.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 6
NM_001394525.1	NP_001381454.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 7
NM_001394526.1	NP_001381455.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 8
NM_001394527.1	NP_001381456.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 9
NM_001394528.1	NP_001381457.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 10
NM_001394529.1	NP_001381458.1	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 11
NM_020183.6	NP_064568.3	aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12055078	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15147242	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	12738229	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15147242	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11018023	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	10864977	GOA
acts upstream of or within circadian rhythm	IDA IDA: Inferred from direct assay	10864977	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10864977	GOA
involved in positive regulation of circadian rhythm	IDA IDA: Inferred from direct assay	12738229	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15147242	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12055078	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CLOCK-BMAL transcription complex	IPI IPI: Inferred from physical interaction	10864977	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12055078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMAL2 Protein Structure

HLH

PAS

PAS_11

0
100
200
300
400
500
600
636 a.a.

Protein Preferred Names

Protein Names

aryl hydrocarbon receptor nuclear translocator-like protein 2

CYCLE-like factor

BMAL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BMAL2	Q8WYA1	CLOCK	Homo sapiens	O15516	Anti Tag CoIP	33961781
Intra	BMAL2	Q8WYA1	CLOCK	Homo sapiens	O15516	Y2H	11018023

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatorenal Syndrome

Hepato-Renal Syndrome	Hepatorenal Failure
Hrf - [Hepatorenal Failure]	Hepatorenal Degeneration
Hepatic Renal Syndrome	Hepatic Renal Failure
Renal Hepatic Failure	Urohepatic Syndrome

Hepatic Vascular Disease

Vascular Disorder Of Liver

Acute Kidney Failure

Acute Renal Failure	Acute Kidney Injury
Renal Failure Acute	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Esophageal Varix

Esophageal Varices	Bleeding Esophageal Varices
Bleeding Oesophageal Varices	Esophageal Varices In Disease Classified Elsewhere, With Bleeding
Esophageal Varices With Bleeding	Esophageal Varices With Bleeding In Disease Ec
Esophageal Varices Without Bleeding	Esophageal Varices Without Mention Of Bleeding

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01530	BMAL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BMAL2	VGNC	VGNC:83500
Rattus norvegicus	BMAL2	RGD	RGD:620230
Mus musculus	BMAL2	MGD	MGI:2684845
Bos taurus	BMAL2	VGNC	VGNC:49075
Canis familiaris	BMAL2	VGNC	VGNC:48873
Macaca mulatta	BMAL2	VGNC	VGNC:99889

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