ENY2 - ENY2 transcription and export complex 2 subunit Gene

Homo sapiens

Also known as DC6; Sus1; e(y)2

Gene ID: 56943 | Gene type: protein coding

About ENY2

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,334,347-109,345,954 (from NCBI)

This gene has 16 transcripts (splice variants) and 261 orthologues. Ubiquitous expression in kidney (RPKM 15.2), bone marrow (RPKM 14.0) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleoplasm. Part of nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ENY2 Products(2)

mRNA	Protein	Name
NM_001193557.2	NP_001180486.1	transcription and mRNA export factor ENY2 isoform 2
NM_020189.6	NP_064574.1	transcription and mRNA export factor ENY2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	18206972	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23591820	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	18206972	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in poly(A)+ mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	23591820	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18206972	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DUBm complex	IDA IDA: Inferred from direct assay	27601583	GOA
part of SAGA complex	IDA IDA: Inferred from direct assay	18206972	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	23591820	GOA
part of transcription export complex 2	IDA IDA: Inferred from direct assay	23591820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENY2 Protein Structure

EnY2

0
101 a.a.

Protein Preferred Names

Protein Names

transcription and mRNA export factor ENY2

enhancer of yellow 2 homolog

ENY2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ENY2	Q9NPA8	ATXN7L3	Homo sapiens	Q14CW9	Y2H Array	32296183
Intra	ENY2	Q9NPA8	ATXN7L3	Homo sapiens	Q14CW9	Anti Tag CoIP	35271311
Intra	ENY2	Q9NPA8	ATXN7L3	Homo sapiens	Q14CW9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7	SCA7
Opca3	Opca Iii
Olivopontocerebellar Atrophy Iii	Opca With Retinal Degeneration
Opca With Macular Degeneration And External Ophthalmoplegia	Adca, Type Ii
Autosomal Dominant Cerebellar Ataxia Type 2	Olivopontocerebellar Atrophy 3
Autosomal Dominant Cerebellar Ataxia, Type Ii	Autosomal Dominant Cerebellar Ataxia Type Ii
Adca2	Adcaii
Ataxia With Pigmentary Retinopathy	Cerebellar Syndrome-Pigmentary Maculopathy Syndrome
Olivopontocerebellar Atrophy With Retinal Degeneration	Spinocerebellar Ataxia-7
Ataxia, Spinocerebellar, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04402	ENY2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENY2	RGD	RGD:1596439
Macaca mulatta	ENY2	VGNC	VGNC:104451
Felis catus	ENY2	VGNC	VGNC:61886
Mus musculus	ENY2	MGD	MGI:1919286
Bos taurus	ENY2	VGNC	VGNC:28514

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