RGMA - repulsive guidance molecule BMP co-receptor a Gene

Homo sapiens

Also known as RGM

Gene ID: 56963 | Gene type: protein coding

About RGMA

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:93,035,271-93,089,211 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 2 paralogues. Biased expression in brain (RPKM 32.8), endometrium (RPKM 14.6) and 13 other tissues.

Summary

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RGMA Products(6)

mRNA	Protein	Name
NM_001166283.2	NP_001159755.1	repulsive guidance molecule A isoform 1
NM_001166286.2	NP_001159758.1	repulsive guidance molecule A isoform 2 precursor
NM_001166287.2	NP_001159759.1	repulsive guidance molecule A isoform 2 precursor
NM_001166288.2	NP_001159760.1	repulsive guidance molecule A isoform 2 precursor
NM_001166289.2	NP_001159761.1	repulsive guidance molecule A isoform 2 precursor
NM_020211.3	NP_064596.2	repulsive guidance molecule A isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables transferrin receptor binding	IPI IPI: Inferred from physical interaction	22728873	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22728873	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGMA Protein Structure

RGM_N

RGM_C

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

repulsive guidance molecule A

RGM domain family, member A

Recombinant RGMA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71003	RGMA Protein, Human (His)	Q96B86-1/AAI51133.1 (P169-G422)	≥95%
HY-P76572	RGMA Protein, Human (HEK293, His)	Q96B86-1 (C48-G422)	≥95%
HY-P78197	RGMA Protein, Human (Biotinylated, HEK293, His-Avi)	Q96B86-1 (C48-G422)	≥95%
HY-P78508	RGMA Protein, Human (HEK293, His-Avi)	Q96B86-1 (C48-G422)	≥95%

Related Diseases

Diseases

Alias

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Intracranial Hypertension

Raised Intracranial Pressure

Amusia

Receptive Amusia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99359	Elezanumab	Inhibitor	99.69%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11894	RGMA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RGMA	RGD	RGD:1311983
Bos taurus	RGMA	VGNC	VGNC:33906
Felis catus	RGMA	VGNC	VGNC:64592
Macaca mulatta	RGMA	VGNC	VGNC:76870
Mus musculus	RGMA	MGD	MGI:2679262
Canis familiaris	RGMA	VGNC	VGNC:45515
Others	RGMA	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.