2. Gene
  3. ACKR3 - atypical chemokine receptor 3 Gene

ACKR3 - atypical chemokine receptor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159

Gene ID: 57007 | Gene type: protein coding

About ACKR3

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:236,537,122-236,582,354 (from NCBI)

This gene has 2 transcripts (splice variants), 252 orthologues, 23 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

ACKR3 Products(6)

mRNA Protein Name
XM_005246098.4 XP_005246155.1 atypical chemokine receptor 3 isoform X1
XM_047445136.1 XP_047301092.1 atypical chemokine receptor 3 isoform X1
NM_001047841.1
NM_020311.3 NP_064707.1 atypical chemokine receptor 3
XM_005246097.4 XP_005246154.1 atypical chemokine receptor 3 isoform X1
XM_047445135.1 XP_047301091.1 atypical chemokine receptor 3 isoform X1

ACKR3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 315)

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  • 362 a.a.
Protein Preferred Names Protein Names

atypical chemokine receptor 3

C-X-C chemokine receptor type 7

G protein-coupled receptor

G-protein coupled receptor 159

G-protein coupled receptor RDC1 homolog

chemokine (C-X-C motif) receptor 7

chemokine orphan receptor 1

Recombinant ACKR3 Proteins

Cat. No. Product Name Accession Purity
HY-P700537 ACKR3 Protein, Human (His-SUMO) P25106 (M1-K40) ≥95%

Related Diseases

Diseases Alias
Oculomotor-Abducens Synkinesis

OCABSN
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Glioma
Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123813 CCX-777 Agonist 98.73% Unkown
HY-159582 ACKR3 agonist 1 Agonist / Unkown
HY-161414 trans-VUF25471 / Unkown
HY-D2201 Fluorescent ACKR3 antagonist 1 / Unkown
HY-RS00162 ACKR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00163 Ackr3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00164 Ackr3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACKR3 MGD MGI:109562
Canis familiaris ACKR3 VGNC VGNC:37509
Rattus norvegicus ACKR3 RGD RGD:620601
Bos taurus ACKR3 VGNC VGNC:25541
Felis catus ACKR3 VGNC VGNC:59511
Macaca mulatta ACKR3 VGNC VGNC:69513
Others ACKR3 NCBI