ACKR3 - atypical chemokine receptor 3 Gene

Homo sapiens

Also known as RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159

Gene ID: 57007 | Gene type: protein coding

About ACKR3

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:236,537,122-236,582,354 (from NCBI)

This gene has 2 transcripts (splice variants), 252 orthologues, 23 paralogues and is associated with 53 phenotypes. Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an Orphan Receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

ACKR3 Products(6)

mRNA	Protein	Name
XM_005246098.4	XP_005246155.1	atypical chemokine receptor 3 isoform X1
XM_047445136.1	XP_047301092.1	atypical chemokine receptor 3 isoform X1
NM_001047841.1
NM_020311.3	NP_064707.1	atypical chemokine receptor 3
XM_005246097.4	XP_005246154.1	atypical chemokine receptor 3 isoform X1
XM_047445135.1	XP_047301091.1	atypical chemokine receptor 3 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-X-C chemokine binding	IMP IMP: Inferred from mutant phenotype	22300987	GOA
enables C-X-C chemokine receptor activity	IMP IMP: Inferred from mutant phenotype	20388803	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19380869	GOA
enables scavenger receptor activity	IMP IMP: Inferred from mutant phenotype	22300987	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20388803	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	20388803	GOA
involved in oculomotor nerve development	IMP IMP: Inferred from mutant phenotype	31211835	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22300987	GOA
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	22300987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	22457824	GOA
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	22457824	GOA
located in endosome	IDA IDA: Inferred from direct assay	22300987	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22300987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACKR3 Protein Structure

7tm_1

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

atypical chemokine receptor 3

C-X-C chemokine receptor type 7	G protein-coupled receptor
G-protein coupled receptor 159	G-protein coupled receptor RDC1 homolog
chemokine (C-X-C motif) receptor 7	chemokine orphan receptor 1

ACKR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACKR3	P25106	CXCR4	Homo sapiens	P61073	PLA	28862946
Intra	ACKR3	P25106	CXCR4	Homo sapiens	P61073	Confocal	21730065
Intra	ACKR3	P25106	CXCR4	Homo sapiens	P61073	BRET	19380869
Intra	ACKR3	P25106	CXCR4	Homo sapiens	P61073	PLA	29386406
Intra	ACKR3	P25106	CXCR4	Homo sapiens	P61073	PLA	27331810
Intra	ACKR3	P25106	AVPR1A	Homo sapiens	P37288	PLA	29386406
Intra	ACKR3	P25106	AVPR1A	Homo sapiens	P37288	BRET	29386406
Intra	ACKR3	P25106	AVPR1A	Homo sapiens	P37288	Anti Tag CoIP	29386406

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACKR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700537	ACKR3 Protein, Human (His-SUMO)	P25106 (M1-K40)	≥95%

Related Diseases

Diseases

Alias

Oculomotor-Abducens Synkinesis

OCABSN

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Glioma

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123813	CCX-777	Agonist	98.73%	Unkown
HY-159582	ACKR3 agonist 1	Agonist	/	Unkown
HY-161414	trans-VUF25471		/	Unkown
HY-D2201	Fluorescent ACKR3 antagonist 1		/	Unkown
HY-RS00162	ACKR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00163	Ackr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00164	Ackr3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ACKR3	MGD	MGI:109562
Canis familiaris	ACKR3	VGNC	VGNC:37509
Rattus norvegicus	ACKR3	RGD	RGD:620601
Bos taurus	ACKR3	VGNC	VGNC:25541
Felis catus	ACKR3	VGNC	VGNC:59511
Macaca mulatta	ACKR3	VGNC	VGNC:69513
Others	ACKR3	NCBI

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