2. Gene
  3. CAMK1D - calcium/calmodulin dependent protein kinase ID Gene

CAMK1D - calcium/calmodulin dependent protein kinase ID Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CKLiK; CaM-K1; CaMKID

Gene ID: 57118 | Gene type: protein coding

About CAMK1D

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:12,349,547-12,835,545 (from NCBI)

This gene has 3 transcripts (splice variants), 267 orthologues and 22 paralogues. Broad expression in brain (RPKM 10.9), skin (RPKM 4.6) and 21 other tissues.

Summary

This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and Apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]

CAMK1D Products(3)

mRNA Protein Name
NM_001351032.2 NP_001337961.1 calcium/calmodulin-dependent protein kinase type 1D isoform 3
NM_020397.4 NP_065130.1 calcium/calmodulin-dependent protein kinase type 1D isoform 1
NM_153498.4 NP_705718.1 calcium/calmodulin-dependent protein kinase type 1D isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
11050006 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32707033 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of CREB transcription factor activity IDA
IDA: Inferred from direct assay
16324104 GOA
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
15840691 GOA
involved in positive regulation of respiratory burst IMP
IMP: Inferred from mutant phenotype
15840691 GOA
involved in regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
17056143 GOA
involved in regulation of granulocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
15840691 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11050006 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16324104 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK1D Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 279)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type 1D

CAMK1D/ANAPC5 fusion

CAMK1D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CAMK1D Q8IU85 CAMK1 Homo sapiens Q14012
Pull Down
32707033
Intra
CAMK1D Q8IU85 CAMK1 Homo sapiens Q14012
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK1D Proteins

Cat. No. Product Name Accession Purity
HY-P7715 CAMKI delta/CAMK1D Protein, Human (GST) Q8IU85-1 (M1-K385) ≥95%

Related Diseases

Diseases Alias
Ceroid Lipofuscinosis, Neuronal, 6a

Neuronal Ceroid Lipofuscinosis 6

CLN6

Vlincl

Cln6 Disease

Ceroid Lipofuscinosis, Neuronal, 6

Late-Infantile Neuronal Ceroid Lipofuscinosis

CLN6A

Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant

Neuronal Ceroid Lipofuscinosis 6a

Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset

Cln6 Disease, Adult Kufs Type A

Cln6 Disease, Late Infantile

Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant

Ceroid Lipofuscinosis Neuronal 6

Cln6-Related Neuronal Ceroid Lipofuscinosis

Late Infantile Neuronal Ceroid Lipofuscinosis

Jansky-Bielschowsky Disease

Lincl

Late Infantile Ncl

Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset

Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis

Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant

Lipofuscinosis, Ceroid, Neuronal, Type 6

Ceroid Lipofuscinosis, Neuronal, 5
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148913 CS587 Inhibitor 98.11% Unkown
HY-148907 CS640 Inhibitor 99.43% Unkown
HY-156871 CAMK1D-IN-1 / Unkown
HY-RS01852 CAMK1D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CAMK1D MGD MGI:2442190
Bos taurus CAMK1D VGNC VGNC:58595
Macaca mulatta CAMK1D VGNC VGNC:70579
Rattus norvegicus CAMK1D RGD RGD:1560691
Canis familiaris CAMK1D VGNC VGNC:38678
Felis catus CAMK1D VGNC VGNC:60329
Others CAMK1D NCBI