PSMD8 - proteasome 26S subunit, non-ATPase 8 Gene

Homo sapiens

Also known as S14; p31; HIP6; HYPF; Nin1p; Rpn12; HEL-S-91n

Gene ID: 5714 | Gene type: protein coding

About PSMD8

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,374,571-38,383,824 (from NCBI)

This gene has 14 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in heart (RPKM 59.1), fat (RPKM 53.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

PSMD8 Products(1)

mRNA	Protein	Name
NM_002812.5	NP_002803.2	26S proteasome non-ATPase regulatory subunit 8

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16990800	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD8 Protein Structure

CSN8_PSD8_EIF3K

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 8

26S proteasome regulatory subunit RPN12

PSMD8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMD8	P48556	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Invasive Bladder Transitional Cell Carcinoma

Invasive Bladder Urothelial Carcinoma

Infiltrating Bladder Urothelial Carcinoma

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11329	PSMD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMD8	VGNC	VGNC:69128
Canis familiaris	PSMD8	VGNC	VGNC:45115
Rattus norvegicus	PSMD8	RGD	RGD:1309842
Mus musculus	PSMD8	MGD	MGI:1888669
Bos taurus	PSMD8	VGNC	VGNC:33472

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