2. Gene
  3. SHC3 - SHC adaptor protein 3 Gene

SHC3 - SHC adaptor protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RAI; NSHC; SHCC; N-Shc

Gene ID: 53358 | Gene type: protein coding

About SHC3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:89,005,771-89,178,818 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.7) and 2 other tissues.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC3 Products(1)

mRNA Protein Name
NM_016848.6 NP_058544.3 SHC-transforming protein 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11877420 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC3 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (155 - 310)

SH2

SH2: SH2 domain (499 - 570)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

SHC-transforming protein 3

SH2 domain protein C3

Related Diseases

Diseases Alias
Spinal Cord Ependymoma

Ependymal Neoplasm Of The Spinal Cord

Spinal Ependymoma

Ependymoma Of Spinal Cord
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12858 SHC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SHC3 VGNC VGNC:46141
Mus musculus SHC3 MGD MGI:106179
Felis catus SHC3 VGNC VGNC:97626
Bos taurus SHC3 VGNC VGNC:34591
Rattus norvegicus SHC3 RGD RGD:69348