SHC3 - SHC adaptor protein 3 Gene

Homo sapiens

Also known as RAI; NSHC; SHCC; N-Shc

Gene ID: 53358 | Gene type: protein coding

About SHC3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:89,005,771-89,178,818 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.7) and 2 other tissues.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC3 Products(1)

mRNA	Protein	Name
NM_016848.6	NP_058544.3	SHC-transforming protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11877420	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC3 Protein Structure

PID

SH2

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

SHC-transforming protein 3

SH2 domain protein C3

SHC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SHC3	Q92529	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	SHC3	Q92529	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SHC3	Q92529	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
Intra	SHC3	Q92529	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	SHC3	Q92529	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	SHC3	Q92529	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	SHC3	Q92529	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	SHC3	Q92529	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	SHC3	Q92529	DOK3	Homo sapiens	Q7L591-3	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	DOK3	Homo sapiens	Q7L591-3	Y2H Array	32296183
Intra	SHC3	Q92529	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	SHC3	Q92529	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	YPEL5	Homo sapiens	P62699	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	YPEL5	Homo sapiens	P62699	Y2H Array	32296183
Intra	SHC3	Q92529	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	SHC3	Q92529	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	SHC3	Q92529	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	SHC3	Q92529	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	SHC3	Q92529	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	SHC3	Q92529	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	SHC3	Q92529	ANKRD10	Homo sapiens	Q9NXR5-2	Validated Y2H	32296183
Intra	SHC3	Q92529	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Array	32296183
Intra	SHC3	Q92529	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	SHC3	Q92529	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	SHC3	Q92529	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	SHC3	Q92529	KIT	Homo sapiens	P10721	FPS	24728074
Intra	SHC3	Q92529	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	TRIM35	Homo sapiens	Q9UPQ4-2	Validated Y2H	32296183
Intra	SHC3	Q92529	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Array	32296183
Intra	SHC3	Q92529	CDCA4	Homo sapiens	Q9BXL8	Validated Y2H	32296183
Intra	SHC3	Q92529	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32296183
Intra	SHC3	Q92529	CDCA4	Homo sapiens	Q9BXL8	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	FTO	Homo sapiens	Q9C0B1-2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	FTO	Homo sapiens	Q9C0B1-2	Validated Y2H	32296183
Intra	SHC3	Q92529	FTO	Homo sapiens	Q9C0B1-2	Y2H Array	32296183
Intra	SHC3	Q92529	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	SHC3	Q92529	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	SHC3	Q92529	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	SHC3	Q92529	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	SHC3	Q92529	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	SHC3	Q92529	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	SMYD3	Homo sapiens	Q9H7B4	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	SMYD3	Homo sapiens	Q9H7B4	Y2H Array	32296183
Intra	SHC3	Q92529	SMYD3	Homo sapiens	Q9H7B4	Validated Y2H	32296183
Intra	SHC3	Q92529	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	SHC3	Q92529	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	SHC3	Q92529	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	PSMD8	Homo sapiens	P48556	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	PSMD8	Homo sapiens	P48556	Y2H Array	32296183
Intra	SHC3	Q92529	BMF	Homo sapiens	Q96LC9	Validated Y2H	32296183
Intra	SHC3	Q92529	BMF	Homo sapiens	Q96LC9	Y2H Array	32296183
Intra	SHC3	Q92529	BMF	Homo sapiens	Q96LC9	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	CCNC	Homo sapiens	P24863	Y2H Array	32296183
Intra	SHC3	Q92529	CEACAM6	Homo sapiens	P40199	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	CEACAM6	Homo sapiens	P40199	Y2H Array	32296183
Intra	SHC3	Q92529	COPS6	Homo sapiens	Q7L5N1	Y2H Array	32296183
Intra	SHC3	Q92529	COPS6	Homo sapiens	Q7L5N1	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	SHC3	Q92529	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	SHC3	Q92529	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	SHC3	Q92529	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	SHC3	Q92529	CT55	Homo sapiens	Q8WUE5	Y2H Array	32296183
Intra	SHC3	Q92529	CT55	Homo sapiens	Q8WUE5	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	PMF1	Homo sapiens	Q6P1K2	Y2H Array	32296183
Intra	SHC3	Q92529	PMF1	Homo sapiens	Q6P1K2	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	STX11	Homo sapiens	O75558	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	STX11	Homo sapiens	O75558	Y2H Array	32296183
Intra	SHC3	Q92529	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	SHC3	Q92529	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	SHC3	Q92529	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	APP	Homo sapiens	P05067	Pull Down	11877420
Intra	SHC3	Q92529	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	SHC3	Q92529	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SHC3	Q92529	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	SHC3	Q92529	KRT86	Homo sapiens	O43790	Y2H Array	32296183
Intra	SHC3	Q92529	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinal Cord Ependymoma

Ependymal Neoplasm Of The Spinal Cord	Spinal Ependymoma
Ependymoma Of Spinal Cord

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12858	SHC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SHC3	VGNC	VGNC:46141
Mus musculus	SHC3	MGD	MGI:106179
Felis catus	SHC3	VGNC	VGNC:97626
Bos taurus	SHC3	VGNC	VGNC:34591
Rattus norvegicus	SHC3	RGD	RGD:69348

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