RALGAPA2 - Ral GTPase activating protein catalytic subunit alpha 2 Gene

Homo sapiens

Also known as p220; AS250; C20orf74; dJ1049G11; bA287B20.1; dJ1049G11.4

Gene ID: 57186 | Gene type: protein coding

About RALGAPA2

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,389,530-20,712,644 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 9.1), placenta (RPKM 6.4) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RALGAPA2 Products(1)

mRNA	Protein	Name
NM_020343.4	NP_065076.2	ral GTPase-activating protein subunit alpha-2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16490346	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RALGAPA2 Protein Structure

Rap_GAP

0
300
600
900
1200
1500
1873 a.a.

Protein Preferred Names

Protein Names

ral GTPase-activating protein subunit alpha-2

250 kDa substrate of Akt

RALGAPA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RALGAPA2	Q2PPJ7	DDI1	Homo sapiens	Q8WTU0	Validated Y2H	32296183
Intra	RALGAPA2	Q2PPJ7	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
Intra	RALGAPA2	Q2PPJ7	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Myasthenic Syndrome 7

Cms7	Congenital Myasthenic Syndrome 7 Presynaptic
Myasthenic Syndrome, Congenital, Type 7, Presynaptic

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11631	RALGAPA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RALGAPA2	VGNC	VGNC:81166
Canis familiaris	RALGAPA2	VGNC	VGNC:45333
Bos taurus	RALGAPA2	VGNC	VGNC:33702
Macaca mulatta	RALGAPA2	VGNC	VGNC:76488
Mus musculus	RALGAPA2	MGD	MGI:3036245
Rattus norvegicus	RALGAPA2	RGD	RGD:1308023

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