ERGIC1 - endoplasmic reticulum-golgi intermediate compartment 1 Gene

Homo sapiens

Also known as AMC2; AMCN; NET24; ERGIC32; ERGIC-32

Gene ID: 57222 | Gene type: protein coding

About ERGIC1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,834,251-172,952,683 (from NCBI)

This gene has 30 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 69.0), adrenal (RPKM 49.7) and 25 other tissues.

Summary

This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]

ERGIC1 Products(1)

mRNA	Protein	Name
NM_001031711.3	NP_001026881.1	endoplasmic reticulum-Golgi intermediate compartment protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15308636	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	15308636	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERGIC1 Protein Structure

ERGIC_N

COPIIcoated_ERV

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

endoplasmic reticulum-Golgi intermediate compartment protein 1

ER-Golgi intermediate compartment 32 kDa protein

ERGIC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ERGIC1	Q969X5	ERGIC3	Homo sapiens	Q9Y282	Crosslink	15308636
Intra	ERGIC1	Q969X5	ERGIC3	Homo sapiens	Q9Y282	IF	15308636

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type	Amcn
Arthrogryposis Multiplex Congenita Neurogenic Type	AMC2
Amc, Neurogenic Type	Neurogenic-Type Arthrogryposis Multiplex Congenita-2
Amc Neurogenic Type	Neurogenic Type Of Amc
Neurogenic Arthrogryposis Multiplex Congenita	Arthrogryposis Multiplex Congenita, Neurogenic

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita	Arthrogryposis
Congenital Multiple Arthrogryposis	Congenital Arthromyodysplasia
Fibrous Ankylosis Of Multiple Joints	Guerin-Stern Syndrome
Guérin-Stern Syndrome	Myodystrophia Fetalis Deformans
Otto Syndrome	Rocher-Sheldon Syndrome
Rossi Syndrome	Amc
Multiple Congenital Arthrogryposis	Arthrogryposis Syndrome
Arthrogryposis, Distal	Distal Arthrogryposis Syndrome
Freeman-Sheldon Syndrome	Arthrogryposis, Distal, Type 2b
Congenital Multiplex Arthrogryposis	Amyoplasia Congenita
Congenital Amyoplasia	Amc - [Arthrogryposis Multiplex Congenita]

Frank-Ter Haar Syndrome

Ter Haar Syndrome	Borrone Dermatocardioskeletal Syndrome
FTHS	Autosomal Recessive Melnick-Needles Syndrome
Borrone Di Rocco Crovato Syndrome	Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay
Melnick-Needles Syndrome, Autosomal Recessive, Formerly	Frank Ter Haar Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04493	ERGIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERGIC1	MGD	MGI:1914708
Rattus norvegicus	ERGIC1	RGD	RGD:1585015
Macaca mulatta	ERGIC1	VGNC	VGNC:82141
Felis catus	ERGIC1	VGNC	VGNC:61939
Bos taurus	ERGIC1	VGNC	VGNC:28578
Canis familiaris	ERGIC1	VGNC	VGNC:40450

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