CLK4 - CDC like kinase 4 Gene

Homo sapiens

Gene ID: 57396 | Gene type: protein coding

About CLK4

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:178,602,664-178,627,050 (from NCBI)

This gene has 13 transcripts (splice variants), 625 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 15.9), bone marrow (RPKM 13.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]

CLK4 Products(1)

mRNA	Protein	Name
NM_020666.3	NP_065717.1	dual specificity protein kinase CLK4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	19168442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK4 Protein Structure

Pkinase

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

dual specificity protein kinase CLK4

protein serine threonine kinase Clk4

CLK4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLK4	Q9HAZ1	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	CLK4	Q9HAZ1	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	CLK4	Q9HAZ1	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	CLK4	Q9HAZ1	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	CLK4	Q9HAZ1	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	CLK4	Q9HAZ1	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	CLK4	Q9HAZ1	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	CLK4	Q9HAZ1	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	CLK4	Q9HAZ1	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	CLK4	Q9HAZ1	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	CLK4	Q9HAZ1	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	25416956
Intra	CLK4	Q9HAZ1	KPNA1	Homo sapiens	P52294	Y2H Array	25416956
Intra	CLK4	Q9HAZ1	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	CLK4	Q9HAZ1	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15338	TG003	Inhibitor	99.57%	Unkown
HY-112296	T025		99.64%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-123600	SRI-29329	Inhibitor	99.73%	Unkown
HY-149262	CLK1-IN-3		98.03%	Unkown
HY-12828A	KH-CB20	Inhibitor	99.80%	Unkown
HY-131978	DB18	Inhibitor	98.27%	Unkown
HY-153708	SGC-CLK-1	Inhibitor	/	Unkown
HY-125202	KuWal151	Inhibitor	/	Unkown
HY-146335	CLK1/4-IN-1	Inhibitor	/	Unkown
HY-15338A	(E/Z)-TG003	Inhibitor	/	Unkown
HY-155723	Leucettinib-92	Inhibitor	/	Unkown
HY-RS02819	CLK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125290	MU1210	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLK4	VGNC	VGNC:27451
Canis familiaris	CLK4	VGNC	VGNC:39349
Macaca mulatta	CLK4	VGNC	VGNC:71173
Felis catus	CLK4	VGNC	VGNC:60965
Rattus norvegicus	CLK4	RGD	RGD:1310274
Mus musculus	CLK4	MGD	MGI:1098551

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