SRRM4 - serine/arginine repetitive matrix 4 Gene

Homo sapiens

Also known as nSR100; KIAA1853; MU-MB-2.76

Gene ID: 84530 | Gene type: protein coding

About SRRM4

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,981,541-119,163,051 (from NCBI)

This gene has 7 transcripts (splice variants) and 108 orthologues. Biased expression in brain (RPKM 5.9) and adrenal (RPKM 0.7).

Summary

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

SRRM4 Products(1)

mRNA	Protein	Name
NM_194286.4	NP_919262.2	serine/arginine repetitive matrix protein 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	29961578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRRM4 Protein Structure

SRRM_C

0
100
200
300
400
500
611 a.a.

Protein Preferred Names

Protein Names

serine/arginine repetitive matrix protein 4

medulloblastoma antigen MU-MB-2.76

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 27

DFNA27	Autosomal Dominant Nonsyndromic Deafness 27
Autosomal Dominant Deafness 27	Deafness, Autosomal Dominant, 27

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13788	SRRM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SRRM4	MGD	MGI:1916205
Canis familiaris	SRRM4	VGNC	VGNC:46814
Bos taurus	SRRM4	VGNC	VGNC:35295
Macaca mulatta	SRRM4	VGNC	VGNC:78011
Rattus norvegicus	SRRM4	RGD	RGD:1560213
Felis catus	SRRM4	VGNC	VGNC:65692

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