2. Gene
  3. SRRM4 - serine/arginine repetitive matrix 4 Gene

SRRM4 - serine/arginine repetitive matrix 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as nSR100; KIAA1853; MU-MB-2.76

Gene ID: 84530 | Gene type: protein coding

About SRRM4

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,981,541-119,163,051 (from NCBI)

This gene has 7 transcripts (splice variants) and 108 orthologues. Biased expression in brain (RPKM 5.9) and adrenal (RPKM 0.7).

Summary

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

SRRM4 Products(1)

mRNA Protein Name
NM_194286.4 NP_919262.2 serine/arginine repetitive matrix protein 4
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
29961578 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRRM4 Protein Structure

SRRM_C

SRRM_C: Serine/arginine repetitive matrix protein C-terminus (457 - 522)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
Protein Preferred Names Protein Names

serine/arginine repetitive matrix protein 4

medulloblastoma antigen MU-MB-2.76

SRRM4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SRRM4 A7MD48 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
Intra
SRRM4 A7MD48 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra
SRRM4 A7MD48 ZNF699 Homo sapiens Q32M78
Y2H Array
32296183
Intra
SRRM4 A7MD48 ZNF699 Homo sapiens Q32M78
Y2H Prey Pooling
32296183
Intra
SRRM4 A7MD48 ZNF699 Homo sapiens Q32M78
Validated Y2H
32296183
Intra
SRRM4 A7MD48 AKAP17A Homo sapiens Q02040
Validated Y2H
32296183
Intra
SRRM4 A7MD48 AKAP17A Homo sapiens Q02040
Y2H Array
32296183
Intra
SRRM4 A7MD48 AKAP17A Homo sapiens Q02040
Y2H Prey Pooling
32296183
Intra
SRRM4 A7MD48 SNRNP70 Homo sapiens P08621
Y2H Array
32296183
Intra
SRRM4 A7MD48 SNRNP70 Homo sapiens P08621
Y2H Prey Pooling
32296183
Intra
SRRM4 A7MD48 SNRNP70 Homo sapiens P08621
Validated Y2H
32296183
Intra
SRRM4 A7MD48 SRRM1 Homo sapiens Q8IYB3
Validated Y2H
32296183
Intra
SRRM4 A7MD48 ZNF286A Homo sapiens Q9HBT8
Validated Y2H
32296183
Intra
SRRM4 A7MD48 SRSF11 Homo sapiens Q05519-2
Validated Y2H
32296183
Intra
SRRM4 A7MD48 CLK1 Homo sapiens P49759-3
Validated Y2H
32296183
Intra
SRRM4 A7MD48 ZRSR2P1 Homo sapiens Q15695
Validated Y2H
32296183
Intra
SRRM4 A7MD48 RBM25 Homo sapiens P49756
Validated Y2H
32296183
Intra
SRRM4 A7MD48 ZNF124 Homo sapiens Q15973
Validated Y2H
32296183
Intra
SRRM4 A7MD48 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra
SRRM4 A7MD48 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
SRRM4 A7MD48 LUC7L2 Homo sapiens Q9Y383
Y2H Prey Pooling
32296183
Intra
SRRM4 A7MD48 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
Intra
SRRM4 A7MD48 LUC7L2 Homo sapiens Q9Y383
Y2H Array
32296183
Intra
SRRM4 A7MD48 RBM39 Homo sapiens Q14498
Validated Y2H
32296183
Intra
SRRM4 A7MD48 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
Intra
SRRM4 A7MD48 WDR5 Homo sapiens P61964
Validated Y2H
32296183
Intra
SRRM4 A7MD48 U2AF1 Homo sapiens Q01081
Validated Y2H
32296183
Intra
SRRM4 A7MD48 CLK4 Homo sapiens Q9HAZ1
Validated Y2H
32296183
Intra
SRRM4 A7MD48 C16orf87 Homo sapiens Q6PH81
Validated Y2H
32296183
Intra
SRRM4 A7MD48 ZRSR2 Homo sapiens Q15696
Validated Y2H
32296183
Intra
SRRM4 A7MD48 RSRC1 Homo sapiens Q96IZ7
Validated Y2H
32296183
Intra
SRRM4 A7MD48 MMTAG2 Homo sapiens Q9BU76
Validated Y2H
32296183
Intra
SRRM4 A7MD48 SNIP1 Homo sapiens Q8TAD8
Validated Y2H
32296183
Intra
SRRM4 A7MD48 SNIP1 Homo sapiens Q8TAD8
Y2H Prey Pooling
32296183
Intra
SRRM4 A7MD48 SNIP1 Homo sapiens Q8TAD8
Y2H Array
32296183
Intra
SRRM4 A7MD48 RBMX2 Homo sapiens Q9Y388
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 27

DFNA27

Autosomal Dominant Nonsyndromic Deafness 27

Autosomal Dominant Deafness 27

Deafness, Autosomal Dominant, 27
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13788 SRRM4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SRRM4 MGD MGI:1916205
Canis familiaris SRRM4 VGNC VGNC:46814
Bos taurus SRRM4 VGNC VGNC:35295
Macaca mulatta SRRM4 VGNC VGNC:78011
Rattus norvegicus SRRM4 RGD RGD:1560213
Felis catus SRRM4 VGNC VGNC:65692