EEA1 - early endosome antigen 1 Gene

Homo sapiens

Also known as MST105; ZFYVE2; MSTP105

Gene ID: 8411 | Gene type: protein coding

About EEA1

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:92,770,637-92,929,295 (from NCBI)

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in esophagus (RPKM 9.9), fat (RPKM 8.8) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in cytosol and early endosome. Is extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EEA1 Products(1)

mRNA	Protein	Name
NM_003566.4	NP_003557.3	early endosome antigen 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	11256955	GOA
enables GTP-dependent protein binding	IDA IDA: Inferred from direct assay	10491193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9697774	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11741531	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21081650	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in vesicle fusion	IMP IMP: Inferred from mutant phenotype	9697774	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	7768953	GOA
located in early endosome	IDA IDA: Inferred from direct assay	11741531	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	7768953	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

early endosome antigen 1

early endosome antigen 1, 162kD

Related Diseases

Diseases

Alias

Subacute Cutaneous Lupus Erythematosus

Lupus Erythematosus Cutaneous Subacute	Lupus Erythematosus, Subacute Cutaneous
Sacle - [Subacute Cutaneous Lupus Erythematosus]	Scle - [Subacute Cutaneous Lupus Erythematosus]

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Oculoglandular Tularemia

Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis	Hme
Human Ehrlichial Infection, Human Monocytic Type

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150058	Bocconoline		≥95.0%	Unkown
HY-RS04172	EEA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EEA1	VGNC	VGNC:54421
Felis catus	EEA1	VGNC	VGNC:61730
Mus musculus	EEA1	MGD	MGI:2442192
Rattus norvegicus	EEA1	RGD	RGD:1310167
Canis familiaris	EEA1	VGNC	VGNC:40205
Macaca mulatta	EEA1	VGNC	VGNC:72161

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