2. Gene
  3. MIB1 - MIB E3 ubiquitin protein ligase 1 Gene

MIB1 - MIB E3 ubiquitin protein ligase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2

Gene ID: 57534 | Gene type: protein coding

About MIB1

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:21,704,916-21,870,953 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 7.2), endometrium (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin Ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

MIB1 Products(1)

mRNA Protein Name
NM_020774.4 NP_065825.1 E3 ubiquitin-protein ligase MIB1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23615451 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIB1 Protein Structure

MIB_HERC2

MIB_HERC2: Mib_herc2 (15 - 74)

ZZ

ZZ: Zinc finger, ZZ type (80 - 119)

MIB_HERC2

MIB_HERC2: Mib_herc2 (154 - 220)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (435 - 527)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (531 - 593)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (596 - 662)

Ank

Ank: Ankyrin repeat (666 - 697)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (817 - 859)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (864 - 906)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (960 - 1001)

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  • 1006 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MIB1

DAPK-interacting protein 1

MIB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
MIB1 Q86YT6 P0DTD1-PRO_0000449627 SARS-CoV-2 P0DTD1-PRO_0000449627
Y2H Array
36217030
Cross
MIB1 Q86YT6 Azi2 Mus musculus Q9QYP6
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

MIB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82146 MIB1 Antibody (YA1891) WB, IHC-P, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Left Ventricular Noncompaction 7

LVNC7

Left Ventricular Non-Compaction 7

Ventricular Noncompaction, Left, Type 7
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Lymphoplasmacyte-Rich Meningioma

Lymphoplasmocyte-Rich Meningioma

Meningioma
Microcystic Meningioma
Juxtacortical Chondroma

Periosteal Chondroma
Diffuse Meningeal Melanocytosis

Diffuse Melanocytosis

Diffuse Melanosis
Foster-Kennedy Syndrome

Disorder Of The Optic Nerve

Optic Nerve Diseases

Disease Of Optic Cranial Nerve

Disease Of Optic Nerve

Disease Of Second Cranial Nerve

Disorder Of Optic Cranial Nerve

Disorder Of Second Cranial Nerve

Disorders Of 2nd Nerve
Meningeal Melanocytoma

Leptomeningeal Melanocytoma

Melanocytoma Of Meninges
Central Nervous System Melanocytic Neoplasm

Primary Melanocytic Lesion Of Meninges

Central Nervous System Primary Melanocytic Lesion

Melanocytic Tumor Of The Cns

Primary Melanocytic Lesions Of The Cns
Spinal Meningioma

Spinal Cord Meningioma

Meningioma, Spine

Meningioma

Meningioma, Benign, No Icd-O Subtype
Spinal Canal And Spinal Cord Meningioma
Intracranial Meningioma

Meningioma
Optic Nerve Glioma

Glioma Of The Optic Nerve
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Optic Nerve Neoplasm

Optic Nerve Neoplasms

Neoplasm Of Optic Nerve

Tumor Of Second Cranial Nerve

Tumour Of Optic Nerve
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08422 MIB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MIB1 MGD MGI:2443157
Rattus norvegicus MIB1 RGD RGD:1307195
Bos taurus MIB1 VGNC VGNC:31455
Macaca mulatta MIB1 VGNC VGNC:104228
Canis familiaris MIB1 VGNC VGNC:43217
Felis catus MIB1 VGNC VGNC:63492