2. Gene
  3. USP36 - ubiquitin specific peptidase 36 Gene

USP36 - ubiquitin specific peptidase 36 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DUB1

Gene ID: 57602 | Gene type: protein coding

About USP36

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,787,381-78,841,439 (from NCBI)

This gene has 25 transcripts (splice variants), 201 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C19 or Ubiquitin-Specific Protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of Autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

USP36 Products(13)

mRNA Protein Name
NM_001321291.2 NP_001308220.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385169.1 NP_001372098.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 1
NM_001385170.1 NP_001372099.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385171.1 NP_001372100.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385172.1 NP_001372101.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385173.1 NP_001372102.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385174.1 NP_001372103.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385175.1 NP_001372104.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385176.1 NP_001372105.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 2
NM_001385177.1 NP_001372106.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 3
NM_001385178.1 NP_001372107.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 3
NM_001385179.1 NP_001372108.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 4
NM_001385180.1 NP_001372109.1 ubiquitin carboxyl-terminal hydrolase 36 isoform 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
35989368 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables histone H2B deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
29274341 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
29274341 GOA
involved in negative regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
22622177 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
19208757 GOA
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
27445338 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
27445338 GOA
involved in regulation of rRNA processing IDA
IDA: Inferred from direct assay
19208757 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27445338 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
19208757 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP36 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (122 - 420)

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  • 1123 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 36

deubiquitinating enzyme 36

USP36 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
USP36 Q9P275 DHX33 Homo sapiens Q9H6R0
Anti Tag CoIP
19615732
Intra
USP36 Q9P275 DHX33 Homo sapiens Q9H6R0
Anti Tag CoIP
33961781
Intra
USP36 Q9P275 DHX33 Homo sapiens Q9H6R0
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15547 USP36 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP36 VGNC VGNC:52844
Felis catus USP36 VGNC VGNC:66882
Mus musculus USP36 MGD MGI:1919594
Canis familiaris USP36 VGNC VGNC:55014
Macaca mulatta USP36 VGNC VGNC:79219
Rattus norvegicus USP36 RGD RGD:1309937
Others USP36 NCBI