DHX33 - DEAH-box helicase 33 Gene

Homo sapiens

Also known as DDX33

Gene ID: 56919 | Gene type: protein coding

About DHX33

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,440,917-5,468,982 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 5.2), appendix (RPKM 3.8) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

DHX33 Products(2)

mRNA	Protein	Name
NM_001199699.2	NP_001186628.1	ATP-dependent RNA helicase DHX33 isoform 2
NM_020162.4	NP_064547.2	ATP-dependent RNA helicase DHX33 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	23871209	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	26100019	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables rDNA binding	IDA IDA: Inferred from direct assay	21930779	GOA
enables ribosomal large subunit binding	IPI IPI: Inferred from physical interaction	26100019	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23871209	GOA
involved in positive regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	21930779	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLRP3 inflammasome complex	IDA IDA: Inferred from direct assay	23871209	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23871209	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	21930779	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	21930779	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23871209	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX33 Protein Structure

DEAD

Helicase_C

HA2

OB_NTP_bind

0
200
400
600
707 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX33

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33

DHX33 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DHX33	Q9H6R0	USP36	Homo sapiens	Q9P275	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156418	KY386	Inhibitor	99.01%	Unkown
HY-RS03752	DHX33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DHX33	MGD	MGI:2445102
Felis catus	DHX33	VGNC	VGNC:61478
Macaca mulatta	DHX33	VGNC	VGNC:71633
Canis familiaris	DHX33	VGNC	VGNC:39943
Bos taurus	DHX33	VGNC	VGNC:54418
Rattus norvegicus	DHX33	RGD	RGD:1307239

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