PHRF1 - PHD and ring finger domains 1 Gene

Homo sapiens

Also known as RNF221; PPP1R125

Gene ID: 57661 | Gene type: protein coding

About PHRF1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:576,470-612,222 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 9.2), spleen (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable RNA polymerase binding activity. Predicted to be involved in mRNA processing and transcription by RNA polymerase II. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

PHRF1 Products(4)

mRNA	Protein	Name
NM_001286581.2	NP_001273510.1	PHD and RING finger domain-containing protein 1 isoform 1
NM_001286582.2	NP_001273511.1	PHD and RING finger domain-containing protein 1 isoform 3
NM_001286583.2	NP_001273512.1	PHD and RING finger domain-containing protein 1 isoform 4
NM_020901.4	NP_065952.2	PHD and RING finger domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHRF1 Protein Structure

zf-RING_2

PHD

0
300
600
900
1200
1500
1649 a.a.

Protein Preferred Names

Protein Names

PHD and RING finger domain-containing protein 1

CTD-binding SR-like protein rA9

PHRF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PHRF1	Q9P1Y6	CSNK2B	Homo sapiens	P67870	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10454	PHRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PHRF1	VGNC	VGNC:32847
Mus musculus	PHRF1	MGD	MGI:2141847
Canis familiaris	PHRF1	VGNC	VGNC:44510
Rattus norvegicus	PHRF1	RGD	RGD:708360
Felis catus	PHRF1	VGNC	VGNC:64154
Macaca mulatta	PHRF1	VGNC	VGNC:75856

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