QSOX1 - quiescin sulfhydryl oxidase 1 Gene

Homo sapiens

Also known as Q6; QSCN6

Gene ID: 5768 | Gene type: protein coding

About QSOX1

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:180,154,869-180,204,030 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in gall bladder (RPKM 86.5), stomach (RPKM 79.3) and 25 other tissues.

Summary

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

QSOX1 Products(2)

mRNA	Protein	Name
NM_001004128.3	NP_001004128.1	sulfhydryl oxidase 1 isoform b precursor
NM_002826.5	NP_002817.2	sulfhydryl oxidase 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables FAD binding	IDA IDA: Inferred from direct assay	20211621	GOA
enables flavin-dependent sulfhydryl oxidase activity	IDA IDA: Inferred from direct assay	17331072	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	17331072	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	23867277	GOA
involved in negative regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	24475161	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	17331072	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	21082674	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10708601	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QSOX1 Protein Structure

Thioredoxin

Evr1_Alr

0
200
400
600
747 a.a.

Protein Preferred Names

Protein Names

sulfhydryl oxidase 1

quiescin Q6 sulfhydryl oxidase 1

QSOX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81376	QSOX1 Antibody (YA1121)	IHC-P	Human

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13750	Ebselen	Inhibitor	99.58%	Yes

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-165245	SBI-183	Inhibitor	/	Unkown
HY-RS11509	QSOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	QSOX1	VGNC	VGNC:33605
Rattus norvegicus	QSOX1	RGD	RGD:68957
Canis familiaris	QSOX1	VGNC	VGNC:45238
Felis catus	QSOX1	VGNC	VGNC:69200
Macaca mulatta	QSOX1	VGNC	VGNC:106478
Mus musculus	QSOX1	MGD	MGI:1330818

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