CCAR2 - cell cycle and apoptosis regulator 2 Gene

Homo sapiens

Also known as DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967

Gene ID: 57805 | Gene type: protein coding

About CCAR2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,604,757-22,621,514 (from NCBI)

This gene has 13 transcripts (splice variants), 137 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.7), brain (RPKM 20.0) and 25 other tissues.

Summary

Enables RNA polymerase II complex binding activity and Enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

CCAR2 Products(4)

mRNA	Protein	Name
NM_001363068.2	NP_001349997.1	cell cycle and apoptosis regulator protein 2 isoform 2
NM_001363069.2	NP_001349998.1	cell cycle and apoptosis regulator protein 2 isoform 2
NM_001393997.1	NP_001380926.1	cell cycle and apoptosis regulator protein 2 isoform 1
NM_021174.6	NP_066997.3	cell cycle and apoptosis regulator protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	22446626	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	18235501	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	18235501	GOA
enables enzyme inhibitor activity	IMP IMP: Inferred from mutant phenotype	19218236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17314511	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	22446626	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IDA IDA: Inferred from direct assay	15824730	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20160719	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20074560	GOA
involved in negative regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	21030595	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	25661920	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	23352644	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23398316	GOA
involved in positive regulation of DNA damage checkpoint	IMP IMP: Inferred from mutant phenotype	23352644	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18235501	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24824780	GOA
involved in regulation of DNA-templated transcription elongation	IMP IMP: Inferred from mutant phenotype	22446626	GOA
involved in regulation of protein deacetylation	IDA IDA: Inferred from direct assay	21030595	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	23398316	GOA
involved in response to UV	IMP IMP: Inferred from mutant phenotype	23352644	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DBIRD complex	IDA IDA: Inferred from direct assay	22446626	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23352644	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15824730	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	15824730	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15824730	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCAR2 Protein Structure

S1-like

DBC1

0
200
400
600
800
923 a.a.

Protein Preferred Names

Protein Names

cell cycle and apoptosis regulator protein 2

cell division cycle and apoptosis regulator protein 2

Related Diseases

Diseases

Alias

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02021	CCAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCAR2	RGD	RGD:1309922
Bos taurus	CCAR2	VGNC	VGNC:26827
Canis familiaris	CCAR2	VGNC	VGNC:38774
Mus musculus	CCAR2	MGD	MGI:2444228
Macaca mulatta	CCAR2	VGNC	VGNC:70611
Felis catus	CCAR2	VGNC	VGNC:60443

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