CYP4F11 - cytochrome P450 family 4 subfamily F member 11 Gene

Homo sapiens

Also known as CYPIVF11

Gene ID: 57834 | Gene type: protein coding

About CYP4F11

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,912,377-15,934,867 (from NCBI)

This gene has 5 transcripts (splice variants), 381 orthologues and 12 paralogues. Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues.

Summary

This gene, CYP4F11, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CYP4F11 Products(2)

mRNA	Protein	Name
NM_001128932.2	NP_001122404.1	cytochrome P450 4F11 precursor
NM_021187.4	NP_067010.3	cytochrome P450 4F11 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid binding	IDA IDA: Inferred from direct assay	18065749	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	15364545	GOA
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA IDA: Inferred from direct assay	18065749	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	18065749	GOA
involved in menaquinone catabolic process	IDA IDA: Inferred from direct assay	24138531	GOA
involved in omega-hydroxylase P450 pathway	IDA IDA: Inferred from direct assay	15364545	GOA
involved in phylloquinone catabolic process	IDA IDA: Inferred from direct assay	24138531	GOA
involved in vitamin K catabolic process	IDA IDA: Inferred from direct assay	24138531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4F11 Protein Structure

p450

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 4F11

3-hydroxy fatty acids omega-hydroxylase CYP4F11

CYP4F11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CYP4F11	Q9HBI6	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	CYP4F11	Q9HBI6	MESD	Homo sapiens	Q14696	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bietti Crystalline Corneoretinal Dystrophy

BCD	Bietti Crystalline Dystrophy
Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy	Bietti Crystalline Retinopathy
Bietti'S Crystalline Dystrophy	Crystalline Retinopathy
Dystrophy, Corneoretinal, Crystalline, Bietti

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03478	CYP4F11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP4F11	RGD	RGD:1559596
Macaca mulatta	CYP4F11	VGNC	VGNC:103612

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