PTPN14 - protein tyrosine phosphatase non-receptor type 14 Gene

Homo sapiens

Also known as PEZ; PTP36; PTPD2; CATLPH

Gene ID: 5784 | Gene type: protein coding

About PTPN14

Cytogenetic location: 1q32.3-q41 Genomic coordinates (GRCh38): 1:214,348,700-214,551,602 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues, 35 paralogues and is associated with 3 phenotypes. Ubiquitous expression in skin (RPKM 9.0), kidney (RPKM 5.5) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or Cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PTPN14 Products(1)

mRNA	Protein	Name
NM_005401.5	NP_005392.2	tyrosine-protein phosphatase non-receptor type 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22525271	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	22525271	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	20826270	GOA
enables transcription coregulator activity	IMP IMP: Inferred from mutant phenotype	22525271	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	20826270	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22948661	GOA
involved in regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	22948661	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10934049	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10934049	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN14 Protein Structure

FERM_N

FERM_M

FERM_C

Y_phosphatase

0
200
400
600
800
1000
1187 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 14

cytoskeletal-associated protein tyrosine phosphatase

PTPN14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN14	Q15678	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	PTPN14	Q15678	YAP1	Homo sapiens	P46937	ITC	25283809
Intra	PTPN14	Q15678	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	PTPN14	Q15678	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	PTPN14	Q15678	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	PTPN14	Q15678	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Choanal Atresia And Lymphedema

Lymphedema-Posterior Choanal Atresia Syndrome	CATLPH
Atresia, Choanal, And Lymphedema

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Leopard Syndrome 2

LPRD2	Noonan Syndrome With Multiple Lentigines 2
Leopard Syndrome, Type 2

Metatypical Basal Cell Carcinoma

Skin Metatypical Carcinoma	Basosquamous Carcinoma Of Skin
Skin Metatypical Basal Cell Carcinoma

Noonan Syndrome 5

NS5	Noonan Syndrome, Type 5

Noonan Syndrome 3

NS3	Noonan Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11419	PTPN14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPN14	MGD	MGI:102467
Bos taurus	PTPN14	VGNC	VGNC:33532
Canis familiaris	PTPN14	VGNC	VGNC:45171
Rattus norvegicus	PTPN14	RGD	RGD:1307885
Macaca mulatta	PTPN14	VGNC	VGNC:76600
Felis catus	PTPN14	VGNC	VGNC:69161

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