ZNF410 - zinc finger protein 410 Gene

Homo sapiens

Also known as APA1; APA-1

Gene ID: 57862 | Gene type: protein coding

About ZNF410

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,886,859-73,932,521 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 23.4), bone marrow (RPKM 18.5) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF410 Products(5)

mRNA	Protein	Name
NM_001242924.2	NP_001229853.1	zinc finger protein 410 isoform a
NM_001242926.2	NP_001229855.1	zinc finger protein 410 isoform c
NM_001242927.2	NP_001229856.1	zinc finger protein 410 isoform d
NM_001242928.2	NP_001229857.1	zinc finger protein 410 isoform e
NM_021188.3	NP_067011.1	zinc finger protein 410 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	33859416	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	33301730	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables sequence-specific double-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	33301730	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	33301730	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	33859416	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	33301730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF410 Protein Structure

zf-C2H2

zf-H2C2_2

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 410

another partner for ARF 1

ZNF410 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF410	Q86VK4	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	ZNF410	Q86VK4	ZNF397	Homo sapiens	Q8NF99	Y2H Prey Pooling	25416956
Intra	ZNF410	Q86VK4	ZNF397	Homo sapiens	Q8NF99	Validated Y2H	25416956
Intra	ZNF410	Q86VK4	ZNF397	Homo sapiens	Q8NF99	Y2H Array	25416956
Intra	ZNF410	Q86VK4	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	ZNF410	Q86VK4	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	ZNF410	Q86VK4	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	ZNF410	Q86VK4	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	ZNF410	Q86VK4	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	ZNF410	Q86VK4	TSGA10	Homo sapiens	Q9BZW7	Y2H Prey Pooling	25416956
Intra	ZNF410	Q86VK4	TSGA10	Homo sapiens	Q9BZW7	Validated Y2H	25416956
Intra	ZNF410	Q86VK4	RAB3IP	Homo sapiens	Q96QF0	Validated Y2H	25416956
Intra	ZNF410	Q86VK4	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 11

SPGF11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16138	ZNF410 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZNF410	VGNC	VGNC:80788
Bos taurus	ZNF410	VGNC	VGNC:37271
Macaca mulatta	ZNF410	VGNC	VGNC:99352
Rattus norvegicus	ZNF410	RGD	RGD:1305636
Canis familiaris	ZNF410	VGNC	VGNC:48722
Mus musculus	ZNF410	MGD	MGI:1289280

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