PTPRJ - protein tyrosine phosphatase receptor type J Gene

Homo sapiens

Also known as DEP1; SCC1; CD148; HPTPeta; R-PTP-J; HPTP eta; R-PTP-ETA

Gene ID: 5795 | Gene type: protein coding

About PTPRJ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,980,559-48,170,839 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 11.4), appendix (RPKM 10.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRJ Products(2)

mRNA	Protein	Name
NM_001098503.2	NP_001091973.1	receptor-type tyrosine-protein phosphatase eta isoform 2 precursor
NM_002843.4	NP_002834.3	receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12370829	GOA
enables cadherin binding	IPI IPI: Inferred from physical interaction	28926625	GOA
enables delta-catenin binding	IPI IPI: Inferred from physical interaction	12370829	GOA
enables gamma-catenin binding	IPI IPI: Inferred from physical interaction	12370829	GOA
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	19494114	GOA
enables phosphatase activity	IDA IDA: Inferred from direct assay	12062403	GOA
enables phosphatase activity	IMP IMP: Inferred from mutant phenotype	11259588	GOA
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	10821867	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10821867	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19332538	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	9531590	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	9780142	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	19494114	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	12913111	GOA
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9780142	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	14709717	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	16682945	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	14709717	GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19836242	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19922411	GOA
involved in negative regulation of platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	14709717	GOA
involved in negative regulation of vascular permeability	IDA IDA: Inferred from direct assay	19332538	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	9531590	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	9780142	GOA
involved in platelet formation	IMP IMP: Inferred from mutant phenotype	30591527	GOA
involved in platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21091576	GOA
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	14709717	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	21091576	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	21091576	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18936167	GOA
involved in regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	12370829	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12913111	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	12370829	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	12913111	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9531590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRJ Protein Structure

fn3

Y_phosphatase

0
300
600
900
1200
1337 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase eta

CD148 antigen

PTPRJ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPRJ	Q12913	KDR	Homo sapiens	P35968	Pull Down	18936167
Intra	PTPRJ	Q12913	KDR	Homo sapiens	P35968	CoIP	18936167
Intra	PTPRJ	Q12913	FLT1	Homo sapiens	P17948	Biochemical	16893970
Intra	PTPRJ	Q12913	MET	Homo sapiens	P08581	Affinity Chrom	12475979
Intra	PTPRJ	Q12913	MET	Homo sapiens	P08581	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	MET	Homo sapiens	P08581	CoIP	12475979
Intra	PTPRJ	Q12913	TEK	Homo sapiens	Q02763	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	GHR	Homo sapiens	P10912	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	CTNNB1	Homo sapiens	P35222	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	CTNNB1	Homo sapiens	P35222	Pull Down	12370829
Intra	PTPRJ	Q12913	GAB1	Homo sapiens	Q13480	Pull Down	12475979
Intra	PTPRJ	Q12913	GAB1	Homo sapiens	Q13480	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	ERBB2	Homo sapiens	P04626	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	PDGFRB	Homo sapiens	P09619	Phosphatase Assay	19167335
Intra	PTPRJ	Q12913	CTNND1	Homo sapiens	O60716	Pull Down	12475979
Intra	PTPRJ	Q12913	CTNND1	Homo sapiens	O60716	Pull Down	12370829
Intra	PTPRJ	Q12913	CTNND1	Homo sapiens	O60716	Biochemical	12370829
Intra	PTPRJ	Q12913	CTNND1	Homo sapiens	O60716	Fluorescence	12370829

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPRJ Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74200	DEP-1/CD148 Protein, Human (341a.a, His)	Q12913-1 (R997-A1337)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Interstitial Keratitis

Cogan Syndrome

Cogan'S Syndrome	Diffuse Interstitual Keratitis
Cogans Syndrome	Oculovestibuloauditory Syndrome

Cd45 Deficiency

Thrombosis

Thrombosis Of Blood Vessel

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Methotrexate-Associated Lymphoproliferation

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1	Persistent Hyperinsulinemic Hypoglycemia Of Infancy
Familial Hyperinsulinemic Hypoglycemia 1	Congenital Hyperinsulinism
Phhi	Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Of Infancy	Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia
Nesidioblastosis Of Pancreas	Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis
Hyperinsulinism, Congenital	Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form
Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency	Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11441	PTPRJ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPRJ	VGNC	VGNC:106883
Felis catus	PTPRJ	VGNC	VGNC:69175
Rattus norvegicus	PTPRJ	RGD	RGD:3454
Macaca mulatta	PTPRJ	VGNC	VGNC:76618
Canis familiaris	PTPRJ	VGNC	VGNC:45190
Mus musculus	PTPRJ	MGD	MGI:104574
Others	PTPRJ	NCBI

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