2. Gene
  3. PTPRK - protein tyrosine phosphatase receptor type K Gene

PTPRK - protein tyrosine phosphatase receptor type K Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as R-PTP-kappa

Gene ID: 5796 | Gene type: protein coding

About PTPRK

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,968,785-128,520,599 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 209 orthologues, 35 paralogues and is associated with 90 phenotypes. Ubiquitous expression in gall bladder (RPKM 16.8), colon (RPKM 13.7) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

PTPRK Products(6)

mRNA Protein Name
NM_001135648.3 NP_001129120.1 receptor-type tyrosine-protein phosphatase kappa isoform a precursor
NM_001291981.2 NP_001278910.1 receptor-type tyrosine-protein phosphatase kappa isoform c precursor
NM_001291982.2 NP_001278911.1 receptor-type tyrosine-protein phosphatase kappa isoform d precursor
NM_001291983.2 NP_001278912.1 receptor-type tyrosine-protein phosphatase kappa isoform e
NM_001291984.2 NP_001278913.1 receptor-type tyrosine-protein phosphatase kappa isoform f precursor
NM_002844.4 NP_002835.2 receptor-type tyrosine-protein phosphatase kappa isoform b precursor

PTPRK Protein Structure

MAM

MAM: MAM domain, meprin/A5/mu (36 - 193)

Ig_2

Ig_2: Immunoglobulin domain (201 - 288)

fn3

fn3: Fibronectin type III domain (296 - 370)

fn3

fn3: Fibronectin type III domain (504 - 582)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (910 - 1140)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1200 - 1434)

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  • 1439 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase kappa

dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa

Related Diseases

Diseases Alias
Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor

Extragonadal Germ Cell Malignant Tumor

Neoplasm Of Extragonadal Germ Cell

Tumor Of Extragonadal Germ Cell
Eye Lymphoma

Malignant Lymphoma Of Eye

Lymphoma Of Eye
Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor

Hematopoietic Neoplasm Of Central Nervous System

Central Nervous System Hematopoietic Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11442 PTPRK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTPRK VGNC VGNC:33552
Mus musculus PTPRK MGD MGI:103310
Canis familiaris PTPRK VGNC VGNC:45191
Felis catus PTPRK VGNC VGNC:69176
Macaca mulatta PTPRK VGNC VGNC:83453
Rattus norvegicus PTPRK RGD RGD:619706
Others PTPRK NCBI