PTPRK - protein tyrosine phosphatase receptor type K Gene

Homo sapiens

Also known as R-PTP-kappa

Gene ID: 5796 | Gene type: protein coding

About PTPRK

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,968,785-128,520,599 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 209 orthologues, 35 paralogues and is associated with 90 phenotypes. Ubiquitous expression in gall bladder (RPKM 16.8), colon (RPKM 13.7) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

PTPRK Products(6)

mRNA	Protein	Name
NM_001135648.3	NP_001129120.1	receptor-type tyrosine-protein phosphatase kappa isoform a precursor
NM_001291981.2	NP_001278910.1	receptor-type tyrosine-protein phosphatase kappa isoform c precursor
NM_001291982.2	NP_001278911.1	receptor-type tyrosine-protein phosphatase kappa isoform d precursor
NM_001291983.2	NP_001278912.1	receptor-type tyrosine-protein phosphatase kappa isoform e
NM_001291984.2	NP_001278913.1	receptor-type tyrosine-protein phosphatase kappa isoform f precursor
NM_002844.4	NP_002835.2	receptor-type tyrosine-protein phosphatase kappa isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	8663237	GOA
enables gamma-catenin binding	IPI IPI: Inferred from physical interaction	8663237	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15899872	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15899872	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	8663237	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	15899872	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	15899872	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	16849327	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	16849327	GOA
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	15899872	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18276111	GOA
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	15899872	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	18276111	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15899872	GOA
involved in negative regulation of keratinocyte proliferation	IDA IDA: Inferred from direct assay	16263724	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	16263724	GOA
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	18276111	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	16849327	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	15899872	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18276111	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	8663237	GOA
located in leading edge membrane	IDA IDA: Inferred from direct assay	15899872	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRK Protein Structure

MAM

Ig_2

fn3

Y_phosphatase

0
300
600
900
1200
1439 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase kappa

dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa

PTPRK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPRK	Q15262	LOX	Homo sapiens	P28300	Anti Tag CoIP	21690299
Intra	PTPRK	Q15262	LOX	Homo sapiens	P28300	Anti Bait CoIP	21690299
Intra	PTPRK	Q15262	INSR	Homo sapiens	P06213	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor	Extragonadal Germ Cell Malignant Tumor
Neoplasm Of Extragonadal Germ Cell	Tumor Of Extragonadal Germ Cell

Eye Lymphoma

Malignant Lymphoma Of Eye

Lymphoma Of Eye

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor	Hematopoietic Neoplasm Of Central Nervous System
Central Nervous System Hematopoietic Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123492	Kentsin	Control	/	Unkown
HY-RS11442	PTPRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPRK	VGNC	VGNC:33552
Mus musculus	PTPRK	MGD	MGI:103310
Canis familiaris	PTPRK	VGNC	VGNC:45191
Felis catus	PTPRK	VGNC	VGNC:69176
Macaca mulatta	PTPRK	VGNC	VGNC:83453
Rattus norvegicus	PTPRK	RGD	RGD:619706
Others	PTPRK	NCBI

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