2. Gene
  3. PTPRO - protein tyrosine phosphatase receptor type O Gene

PTPRO - protein tyrosine phosphatase receptor type O Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NPHS6; PTPU2; GLEPP1; PTP-OC; PTP-U2; PTPROT; R-PTP-O

Gene ID: 5800 | Gene type: protein coding

About PTPRO

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,322,508-15,598,331 (from NCBI)

This gene has 26 transcripts (splice variants), 220 orthologues, 35 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.7), brain (RPKM 2.7) and 11 other tissues.

Summary

This gene encodes a member of the R3 subtype family of receptor-type Protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of Apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of Cancer. [provided by RefSeq, May 2011]

PTPRO Products(6)

mRNA Protein Name
NM_002848.4 NP_002839.1 receptor-type tyrosine-protein phosphatase O isoform b precursor
NM_030667.3 NP_109592.1 receptor-type tyrosine-protein phosphatase O isoform a precursor
NM_030668.3 NP_109593.1 receptor-type tyrosine-protein phosphatase O isoform d
NM_030669.3 NP_109594.1 receptor-type tyrosine-protein phosphatase O isoform c
NM_030670.3 NP_109595.1 receptor-type tyrosine-protein phosphatase O isoform d
NM_030671.3 NP_109596.1 receptor-type tyrosine-protein phosphatase O isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cadherin binding IPI
IPI: Inferred from physical interaction
28926625 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19167335 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
19167335 GOA
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
19233845 GOA
Biological Process GO Annotation Evidence Reference Source
involved in glomerulus development IMP
IMP: Inferred from mutant phenotype
21722858 GOA
involved in monocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
19233845 GOA
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
19233845 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRO Protein Structure

fn3

fn3: Fibronectin type III domain (435 - 521)

fn3

fn3: Fibronectin type III domain (725 - 800)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (962 - 1193)

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  • 1216 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase O

PTP phi

PTPRO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PTPRO Q16827 MET Homo sapiens P08581
Phosphatase Assay
19167335
Intra PTPRO Q16827 MET Homo sapiens P08581
Pull Down
28330616
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 6

NPHS6

Nephrotic Syndrome Type 6

Nephrotic Syndrome 6
Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Genetic Srns

Hereditary Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Nephrotic Syndrome

Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive

Srn1
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Focal Segmental Glomerulosclerosis 7

FSGS7

Glomerulosclerosis, Focal Segmental, 7

Glomerulosclerosis, Focal Segmental, Type 7
Focal Segmental Glomerulosclerosis 9

FSGS9

Glomerulosclerosis, Focal Segmental, 9

Glomerulosclerosis, Focal Segmental, Type 9
Familial Nephrotic Syndrome

Congenital Nephrotic Syndrome

Nephrosis, Congenital

Finnish Congenital Nephrotic Syndrome
Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome
Alport Syndrome

Hereditary Nephritis

Alport Syndrome, X-Linked

Hemorrhagic Hereditary Nephritis

Congenital Hereditary Hematuria

Hemorrhagic Familial Nephritis

Familial Nephritis

Thin Basement Membrane Disease

Thin Basement Membrane Nephropathy

Hematuria-Nephropathy-Deafness Syndrome

Hematuric Hereditary Nephritis

Hereditary Familial Congenital Hemorrhagic Nephritis

Hereditary Hematuria Syndrome

Hereditary Interstitial Pyelonephritis

Alport Deafness-Nephropathy

Alport Hearing Loss-Nephropathy

Alports Syndrome

Nephritis, Hereditary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11446 PTPRO Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTPRO VGNC VGNC:45195
Macaca mulatta PTPRO VGNC VGNC:100096
Bos taurus PTPRO VGNC VGNC:33555
Felis catus PTPRO VGNC VGNC:69179
Rattus norvegicus PTPRO RGD RGD:62068
Mus musculus PTPRO MGD MGI:1097152