PTPRR - protein tyrosine phosphatase receptor type R Gene

Homo sapiens

Also known as PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7

Gene ID: 5801 | Gene type: protein coding

About PTPRR

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,638,073-70,920,738 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.7), colon (RPKM 3.2) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine Phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

PTPRR Products(4)

mRNA	Protein	Name
NM_001207015.2	NP_001193944.1	receptor-type tyrosine-protein phosphatase R isoform 3
NM_001207016.1	NP_001193945.1	receptor-type tyrosine-protein phosphatase R isoform 4
NM_002849.4	NP_002840.2	receptor-type tyrosine-protein phosphatase R isoform 1 precursor
NM_130846.3	NP_570897.2	receptor-type tyrosine-protein phosphatase R isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10601328	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2 signaling pathway	IMP IMP: Inferred from mutant phenotype	21724833	GOA
involved in in utero embryonic development	IEP IEP: Inferred from expression pattern	10601328	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21724833	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	21724833	GOA
NOT involved in regulation of homophilic cell adhesion	IMP IMP: Inferred from mutant phenotype	21724833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRR Protein Structure

Y_phosphatase

0
200
400
600
657 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase R

Ch-1 PTPase

PTPRR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPRR	Q15256	INSR	Homo sapiens	P06213	Ub Reconstruction	28065597
Intra	PTPRR	Q15256	ERBB2	Homo sapiens	P04626	Ub Reconstruction	28065597
Intra	PTPRR	Q15256	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	33961781
Intra	PTPRR	Q15256	MAPK14	Homo sapiens	Q16539	Phosphatase Assay	10601328
Intra	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	Phosphatase Assay	10601328
Intra	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	IF	10601328
Intra	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 84a

DFNB84A	Deafness, Autosomal Recessive 84
Autosomal Recessive Nonsyndromic Deafness 84a	Dfnb84
Deafness, Autosomal Recessive 84a, With Vestibular Dysfunction	Autosomal Recessive Deafness 84a
Autosomal Recessive Deafness 84a With Vestibular Dysfunction	Deafness, Autosomal Recessive, 84a
Deafness Autosomal Recessive 84	Deafness Autosomal Recessive 84a With Vestibular Dysfunction
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 84	Deafness, Autosomal Recessive, Type 84a

Autosomal Recessive Nonsyndromic Deafness 70

Deafness, Autosomal Recessive 70	Autosomal Recessive Deafness 70
Dfnb70	Deafness, Autosomal Recessive, Type 70

Deafness, Autosomal Dominant 2a

DFNA2A	Autosomal Dominant Nonsyndromic Deafness 2a
Autosomal Dominant Deafness 2a	Deafness, Autosomal Dominant, 2a
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 2a	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 2a
Deafness, Autosomal Dominant, Type 2a

Deafness, Autosomal Dominant 50

DFNA50	Autosomal Dominant Nonsyndromic Deafness 50
Autosomal Dominant Deafness 50	Deafness, Autosomal Dominant, Type 50

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Deafness, Autosomal Recessive 12

DFNB12	Deafness, Autosomal Recessive 12, Modifier Of
Autosomal Recessive Nonsyndromic Deafness 12	Autosomal Recessive Deafness 12
Deafness, Autosomal Recessive, 12	Congenital Neurosensory Deafness Autosomal Recessive 12
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12
Deafness, Autosomal Recessive, Type 12

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141800	MurA-IN-1	Inhibitor	99.32%	Unkown
HY-RS11448	PTPRR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTPRR	VGNC	VGNC:76621
Felis catus	PTPRR	VGNC	VGNC:69180
Rattus norvegicus	PTPRR	RGD	RGD:620780
Canis familiaris	PTPRR	VGNC	VGNC:45197
Bos taurus	PTPRR	VGNC	VGNC:33557
Mus musculus	PTPRR	MGD	MGI:109559

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