RAD1 - RAD1 checkpoint DNA exonuclease Gene

Homo sapiens

Also known as REC1; HRAD1

Gene ID: 5810 | Gene type: protein coding

About RAD1

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:34,905,260-34,915,504 (from NCBI)

This gene has 7 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 6.2), adrenal (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and Other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

RAD1 Products(1)

mRNA	Protein	Name
NM_002853.4	NP_002844.1	cell cycle checkpoint protein RAD1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10359610	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21659603	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21659603	GOA
involved in meiotic recombination checkpoint signaling	IGI IGI: Inferred from genetic interaction	9716408	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of checkpoint clamp complex	IDA IDA: Inferred from direct assay	31776186	GOA
located in chromosome	IDA IDA: Inferred from direct assay	9716408	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9716408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD1 Protein Structure

Rad1

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

cell cycle checkpoint protein RAD1

DNA repair exonuclease REC1

RAD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAD1	O60671	HUS1	Homo sapiens	O60921	Y2H	10359610
Intra	RAD1	O60671	RAD9A	Homo sapiens	Q99638	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11596	RAD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAD1	VGNC	VGNC:110439
Rattus norvegicus	RAD1	RGD	RGD:1306496
Felis catus	RAD1	VGNC	VGNC:102301
Canis familiaris	RAD1	VGNC	VGNC:45310
Mus musculus	RAD1	MGD	MGI:1316678
Bos taurus	RAD1	VGNC	VGNC:33677
Others	RAD1	NCBI

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