RAD9A - RAD9 checkpoint clamp component A Gene

Homo sapiens

Also known as RAD9

Gene ID: 5883 | Gene type: protein coding

About RAD9A

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,391,986-67,398,412 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 9.1), skin (RPKM 8.8) and 25 other tissues.

Summary

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RAD9A Products(2)

mRNA	Protein	Name
NM_001243224.1	NP_001230153.1	cell cycle checkpoint control protein RAD9A isoform 2
NM_004584.3	NP_004575.1	cell cycle checkpoint control protein RAD9A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	10713044	GOA
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	11971963	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15326225	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10846170	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10359610	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12628935	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21659603	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	9872989	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21659603	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of checkpoint clamp complex	IDA IDA: Inferred from direct assay	31776186	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12628935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD9A Protein Structure

Rad9

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

cell cycle checkpoint control protein RAD9A

DNA repair exonuclease rad9 homolog A

RAD9A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Anti Tag CoIP	35271311
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Anti Bait CoIP	10359610
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H Prey Pooling	32296183
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H Array	32296183
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H	10359610
Intra	RAD9A	Q99638	RAD1	Homo sapiens	O60671	Anti Tag CoIP	10359610
Intra	RAD9A	Q99638	RAD1	Homo sapiens	O60671	Anti Tag CoIP	35271311
Intra	RAD9A	Q99638	RAD17	Homo sapiens	O75943	Anti Tag CoIP	35271311
Intra	RAD9A	Q99638	RAD17	Homo sapiens	O75943	Anti Bait CoIP	20424596

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11614	RAD9A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAD9A	RGD	RGD:2319938
Macaca mulatta	RAD9A	VGNC	VGNC:76648
Bos taurus	RAD9A	VGNC	VGNC:33689
Felis catus	RAD9A	VGNC	VGNC:69218
Mus musculus	RAD9A	MGD	MGI:1328356
Canis familiaris	RAD9A	VGNC	VGNC:45322

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