RABGGTB - Rab geranylgeranyltransferase subunit beta Gene

Homo sapiens

Also known as GGTB

Gene ID: 5876 | Gene type: protein coding

About RABGGTB

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:75,786,194-75,795,090 (from NCBI)

This gene has 14 transcripts (splice variants), 227 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 28.6), kidney (RPKM 27.1) and 25 other tissues.

Summary

This gene encodes the beta-subunit of the Enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

RABGGTB Products(1)

mRNA	Protein	Name
NM_004582.4	NP_004573.2	geranylgeranyl transferase type-2 subunit beta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12620389	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RABGGTB Protein Structure

SQHop_cyclase_N

Prenyltrans

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

geranylgeranyl transferase type-2 subunit beta

GGTase-II-beta

RABGGTB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RABGGTB	P53611	TAFA1	Homo sapiens	Q7Z5A9	Validated Y2H	25416956
Intra	RABGGTB	P53611	TMEM25	Homo sapiens	Q86YD3	Y2H Prey Pooling	25416956
Intra	RABGGTB	P53611	TMEM25	Homo sapiens	Q86YD3	Y2H Array	25416956
Intra	RABGGTB	P53611	TMEM25	Homo sapiens	Q86YD3	Validated Y2H	25416956
Intra	RABGGTB	P53611	B4GALT7	Homo sapiens	Q9UBV7	Validated Y2H	32296183
Intra	RABGGTB	P53611	B4GALT7	Homo sapiens	Q9UBV7	Y2H Array	25416956
Intra	RABGGTB	P53611	B4GALT7	Homo sapiens	Q9UBV7	Y2H Prey Pooling	25416956
Intra	RABGGTB	P53611	ARAF	Homo sapiens	P10398	Y2H	12620389
Intra	RABGGTB	P53611	WDR4	Homo sapiens	P57081	Validated Y2H	25416956
Intra	RABGGTB	P53611	WDR4	Homo sapiens	P57081	Validated Y2H	32296183
Intra	RABGGTB	P53611	RABGGTA	Homo sapiens	Q92696	Validated Y2H	32296183
Intra	RABGGTB	P53611	RABGGTA	Homo sapiens	Q92696	Anti Tag CoIP	33961781
Intra	RABGGTB	P53611	RABGGTA	Homo sapiens	Q92696	Anti Tag CoIP	28514442
Intra	RABGGTB	P53611	RABGGTA	Homo sapiens	Q92696	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Choroideremia

CHM	Tcd
Progressive Tapetochoroidal Dystrophy	Choroidal Sclerosis
Tapetochoroidal Dystrophy, Progressive	Progressive Choroidal Atrophy
Tapetochoroidal Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11588	RABGGTB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RABGGTB	VGNC	VGNC:76641
Mus musculus	RABGGTB	MGD	MGI:99537
Canis familiaris	RABGGTB	VGNC	VGNC:45304
Felis catus	RABGGTB	VGNC	VGNC:69208
Bos taurus	RABGGTB	VGNC	VGNC:33671
Rattus norvegicus	RABGGTB	RGD	RGD:3530

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