TAFA1 - TAFA chemokine like family member 1 Gene

Homo sapiens

Also known as TAFA-1; FAM19A1

Gene ID: 407738 | Gene type: protein coding

About TAFA1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,991,544-68,545,621 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Biased expression in brain (RPKM 6.6) and prostate (RPKM 0.3).

Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

TAFA1 Products(2)

mRNA	Protein	Name
NM_001252216.2	NP_001239145.1	chemokine-like protein TAFA-1 precursor
NM_213609.4	NP_998774.2	chemokine-like protein TAFA-1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	29453251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAFA1 Protein Structure

TAFA

0
100
133 a.a.

Protein Preferred Names

Protein Names

chemokine-like protein TAFA-1

family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

TAFA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAFA1	Q7Z5A9	RABGGTB	Homo sapiens	P53611	Y2H Array	25416956
Intra	TAFA1	Q7Z5A9	RABGGTB	Homo sapiens	P53611	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TAFA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79169	TAFA1/FAM19A1 Protein, Human	Q7Z5A9/NP_998774 (S26-T133)	≥95%

Related Diseases

Diseases

Alias

Lissencephaly 9 With Complex Brainstem Malformation

LIS9	Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14179	TAFA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TAFA1	VGNC	VGNC:78188
Rattus norvegicus	TAFA1	RGD	RGD:1563030
Bos taurus	TAFA1	VGNC	VGNC:28777
Mus musculus	TAFA1	MGD	MGI:2443695
Canis familiaris	TAFA1	VGNC	VGNC:82300
Felis catus	TAFA1	VGNC	VGNC:102710
Others	TAFA1	NCBI

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